Search for dissertations about: "imaging biomarker"

Showing result 1 - 5 of 85 swedish dissertations containing the words imaging biomarker.

2. 1. Multiparametric MRI for evaluation of tumour treatment response : Studies of 177Lu-octreotate therapy of neuroendocrine tumour

   Author : Mikael Montelius; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Functional imaging; IVIM; MRI; DWI; DCE; histology; 177Lu-octreotate; small intestine neuroendocrine tumour; NET; diffusion; perfusion; semi-quantitative; proteomics; ionizing radiation; biology; imaging biomarker;

   Abstract : Clinical assessment of tumour response to treatment largely relies on estimates of tumour size by, e.g., measuring the largest tumour diameters on magnetic resonance (MR) or computed tomography (CT) images, weeks or months after treatment. READ MORE

4. 2. Measurement of T1 relaxation time in lungs - Preclinical and clinical MRI applications to COPD

   Author : Daniel Alamidi; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Magnetic Resonance Imaging; biomarker; tobacco smoke; mouse; smoking; lung imaging; Chronic Obstructive Pulmonary Disease; ultrashort echo time UTE ; T1 mapping; longitudinal relaxation time;

   Abstract : Monitoring of regional lung function in clinical trials of chronic obstructive pulmonary disease (COPD) requires alternative endpoints beyond global pulmonary function tests (PFTs), which is the most common approach for diagnosing lung function abnormalities in humans. A promising magnetic resonance imaging (MRI) biomarker of lung disease in humans and animals is the T1 relaxation parameter. READ MORE

5. 3. Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure

   Author : Nils Rudqvist; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astatine-211; iodine-131; radionuclide therapy; nuclear medicine; environmental exposure; thyroid; radiation biology; transcriptomics; proteomics; ionizing radiation; toxicity; normal tissue damage; microarray; LC-MS; biomarker;

   Abstract : Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. READ MORE

6. 4. PET imaging of beta-cell mass

   Author : Pierre Cheung; Olof Eriksson; Weibo Cai; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET imaging; diabetes; beta-cell mass; affibody; SC-islets; Medicinal Chemistry; Läkemedelskemi;

   Abstract : A hallmark of diabetes is the progressive loss of the beta-cell mass (BCM) and function. Most of the diagnostic methods for diabetes are mostly reflective of the beta-cell function, whereas current methodologies for studying the beta-cell mass are limited to post-mortem biopsies or highly invasive methods. READ MORE

7. 5. Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease

   Author : Wojciech Michno; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; beta-amyloid; electron microscopy; imaging mass spectrometry; lipids; luminescent conjugated oligothiophenes; matrix-assisted laser desorption ionization mass spectrometry MALDI-MS ; molecular imaging; nanoscale secondary ion mass spectrometry NanoSIMS ; neurodegeneration; peptides;

   Abstract : Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired amyloid-positive (CU-AP) individuals, but these Aβ plaques are primarily diffuse in structure. READ MORE