Search for dissertations about: "imaging mass spectrometry"

Showing result 21 - 25 of 90 swedish dissertations containing the words imaging mass spectrometry.

  2. 21. Liquid Chromatography – Mass Spectrometry Analysis of Short-lived Tracers in Biological Matrices : Exploration of Radiotracer Chemistry as an Analytical Tool

    Author : Martin Lavén; Karin Markides; Bengt Långström; Rolf Ekman; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; liquid chromatography - mass spectrometry; radiotracer chemistry; positron emission tomography; biological samples; radionuclide imaging; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Liquid chromatography – mass spectrometry (LC-MS) methods were developed for the analysis of positron emission tomography (PET) radiotracers in biological matrices. Additionally, radiotracer chemistry was explored as an analytical tool for supporting LC-MS method development and imaging molecular interactions in miniaturised chemical analysis systems. READ MORE

  4. 22. Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease

    Author : Ibrahim Kaya; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Lipids; Amyloid plaques; Mass spectrometry imaging; MALDI; Trimodal MALDI; Static MALDI; Dual polarity MALDI-MSI on the same pixel points; Neurodegeneration; Immunopathology; Amyloid peptides; APOE; Myelin; Sulfatides; 5xFAD; tgSwe; tgArcSwe; APP;

    Abstract : Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. READ MORE

  5. 23. Mass spectrometry based analysis of drugs, neurotransmitters and lipids in invertebrate model systems

    Author : Nhu TN Phan; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; CE-MS; Imaging mass spectrometry; Lipids; Neurotransmitters; Drug; Drosophila; C. elegans;

    Abstract : Mass spectrometry (MS) is one of the most universal analytical techniques due to its label-free detection principle and high chemical specificity, high selectivity, and sensitivity. MS is diverse with many different types of systems to meet different analytical demands from various research areas. READ MORE

  6. 24. Mass spectrometry of biopolymers based on ion-induced desorption

    Author : Roman Alexandrovich Zubarev; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Strålningsvetenskap; Radiation biology; Strålningsbiologi; Ion Physics; jonfysik;

    Abstract : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. READ MORE

  7. 25. Applications of nanospray desorption electrospray ionization mass spectrome : Analysis of lipids and metabolites in brain tissue sections and single cells

    Author : Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Leopold Ilag; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nano-DESI; single cell analysis; small molecule neurotransmitters; mass spectrometry imaging; MSI; GABA; Glutamate; Acetylcholine; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : .... READ MORE