Search for dissertations about: "imatinib on Glioblastoma"
Found 4 swedish dissertations containing the words imatinib on Glioblastoma.
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1. Molecular determinants of glioma subsets with distinct histology or sensitivity to signal transduction inhibitors
Abstract : Gliomas are brain tumors that currently are treated with surgery, radiation and chemotherapy. Less than 7.5% of patients with GBM survive more than 2 years after diagnosis. READ MORE
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2. Mechanisms determining efficacy of tyrosine kinase-targeting anti-cancer drugs
Abstract : The expanding field of cancer research and the introduction of multiple molecular biology techniques have significantly improved cancer drug discovery, presented new drugs, including tyrosine kinase inhibitors, and thereby gave new hope to the cancer patients and their oncologists. Using this knowledge it is now becoming increasingly possible to determine outcome of malignant disease more accurately, to estimate response to specific therapies and to get closer to the ideal of personalized targeted therapy adjusted to each patient, and to the specific cancer type and its unique genetic profile. READ MORE
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3. Experimental combination therapy of brain cancer cell models
Abstract : Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and adults, respectively. We have been investigating if combination therapy using histone deacetylase inhibitors (HDACi) and receptor tyrosine kinase inhibitors (RTKi) will enhance glioblastoma and medulloblastoma cell killing. READ MORE
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4. Analyses of Akt and PDGF receptor expression and activation in human tumors
Abstract : These studies aimed at developing methodology for detection of proteins involved in cancer and the evaluation of their prognostic significance in human tumors. Signal transduction profiling of tumors are becoming increasingly interesting based on the accumulating evidence of its prognostic and drug response-predicative value. READ MORE