Search for dissertations about: "immature brain"

Showing result 1 - 5 of 81 swedish dissertations containing the words immature brain.

  2. 1. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury

    Author : Pernilla Svedin; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; LPS; immature; brain; inflammation; NAC; melatonin; G-2mPE; MMP-9; MMP-12;

    Abstract : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. READ MORE

  4. 2. The role of bacterial endotoxin in the immature brain

    Author : Saskia Eklind; Göteborgs universitet; []
    Keywords : lipopolysaccharide; hypoxia-ischemia; immature; temperature; cerebral blood flow; blood glucose; inflammation; apoptosis; microarray; preconditioning;

    Abstract : Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, LPS) on hypoxic-ischemic (HI) injury in the immature rat brain, and to evaluate possible underlying mechanisms of increased sensitivity. READ MORE

  5. 3. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia

    Author : Xiaoyang Wang; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; neonatal; caspase; ERK; XIAP; EPO; asialoEPO; brain;

    Abstract : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. READ MORE

  6. 4. Inflammation in the immature brain: The role of Toll like receptors

    Author : Linnea Stridh; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; immature brain; inflammation; innate immunity; Toll-like receptors;

    Abstract : Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after infectious and endogenous, non-infectious, stimuli. READ MORE

  7. 5. Aspects of pathological apoptosis in the immature brain after hypoxia-ischemia

    Author : Ulrika Hallin; Göteborgs universitet; []
    Keywords : neonatal; rat; brain; hypoxia-ischemia; necrosis; apoptosis; calpain; caspase; Bcl-2; Bax; mitochondria; calcineurin.;

    Abstract : The cause of mechanisms underlying perinatal brain injury is not fully known, but it results in a wide variety of neurological impairments in the affected children. When injured, neurons of the newborn brain are prone to undergo programmed cell death, apoptosis, since this genetic program is normally activated in some cells during development of the nervous system, even in the perinatal period. READ MORE