Search for dissertations about: "immature rats"

Showing result 1 - 5 of 47 swedish dissertations containing the words immature rats.

  2. 1. The role of bacterial endotoxin in the immature brain

    Author : Saskia Eklind; Göteborgs universitet; []
    Keywords : lipopolysaccharide; hypoxia-ischemia; immature; temperature; cerebral blood flow; blood glucose; inflammation; apoptosis; microarray; preconditioning;

    Abstract : Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, LPS) on hypoxic-ischemic (HI) injury in the immature rat brain, and to evaluate possible underlying mechanisms of increased sensitivity. READ MORE

  4. 2. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury

    Author : Pernilla Svedin; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; LPS; immature; brain; inflammation; NAC; melatonin; G-2mPE; MMP-9; MMP-12;

    Abstract : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. READ MORE

  5. 3. Hypoxic-ischemic injury in the immature brain. Role of mitochondria, caspases and NMDA receptors

    Author : Malgorzata Puka-Sundvall; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neonatal; immature rats; hypoxia-ischemia; brain damage; calcium; mitochondria; permeability transition; apoptosis; caspase-3; NMDA receptor; electron microscopy;

    Abstract : .... READ MORE

  6. 4. Anabolic Androgenic Steroids : Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol

    Author : Sofia Zelleroth; Mathias Hallberg; Astrid Bjørnebekk; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anabolic androgenic steroids; testosterone; nandrolone; trenbolone; stanozolol; central nervous system; primary cortical cell cultures; rats; multivariate concentric square field; novel object recognition.; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The use of anabolic androgenic steroids (AAS) for recreational purposes is a health concern, as long-term AAS-use in supraphysiological doses is associated with severe physical and psychological adverse effects. Several behavioral and cognitive problems are reported after long-term AAS-use, and alterations in brain morphology as well as neurotransmitter systems have been reported. READ MORE

  7. 5. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia

    Author : Xiaoyang Wang; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; neonatal; caspase; ERK; XIAP; EPO; asialoEPO; brain;

    Abstract : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. READ MORE