Search for dissertations about: "immediate-early genes"

Showing result 1 - 5 of 31 swedish dissertations containing the words immediate-early genes.

2. 1. Effects of ethanol on the expression of immediate-early genes in nerve cells

   Author : Wei-Qun Ding; Institutionen för laboratoriemedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroadaptation; the central nervous system; AP-1; junD; junB; c-jun; fosB; c-fos; neuroblastoma SH-SY5Y; ethanol; immediate-early genes; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Immediate-early genes of the fos and jun families encode proteins that dimerize to form a complex of activator protein 1 and regulate the expression of a number of genes in the nervous system. Ethanol has previously been shown to induce alterations in expression of fos and jun genes in the brain. READ MORE

4. 2. Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy

   Author : Tereza Planck; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; association study; Graves’ disease; Graves’ ophthalmopathy; immediate early genes; inflammation; adipogenesis; thyrostimulin; BTG2; CYR61; COX2; ZFP36; gene expression; SCD; SNP;

   Abstract : Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. READ MORE

5. 3. Methodological studies of eicosanoid enzyme gene expression in vascular endothelium exposed to biomechanical stress

   Author : Roya Doroudi; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostanoids; endothelium; quantitative RT-PCR; perfusion model; shear stress; intraluminal pressure; immediate-early genes;

   Abstract : Prostaglandins are the major eicosanoids synthesized by vascular endothelial cells, and the vasculature is an important target organ for their bioactive metabolites. In vitro studies have shown that biomechanical forces are important regulators of vascular expression of prostanoid enzymes and release of metabolites. READ MORE

6. 4. Transcriptional dysregulation in L-DOPA-induced dyskinesia

   Author : Malin Andersson; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; neurofysiologi; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; CREB; jun; fos; immediate early genes; prodynorphin; striatal plasticity; Parkinson s disease; dyskinesia; Klinisk genetik;

   Abstract : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. READ MORE

7. 5. NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection

   Author : Nikolaos Volakakis; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : NR4A receptors show distinct properties that make them unique within the family of nuclear receptors. They lack a ligand-binding cavity and a canonical coactivator-binding site and they are induced both in vivo and in vitro in an immediate early way by an extremely wide repertoire of substances/conditions. READ MORE