Search for dissertations about: "immobilized protease"
Showing result 1 - 5 of 10 swedish dissertations containing the words immobilized protease.
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1. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery
Abstract : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. READ MORE
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2. Studies of cell migration and matrix protease production in human lung cancer cell lines
Abstract : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. READ MORE
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3. Biological control of plant-parasitic nematodes by the fungus Clonostachys rosea
Abstract : Plant diseases caused by plant-parasitic nematodes are serious constraints to sustainable crop production due to high yield losses, the persistent nature of these nematodes and a lack of efficient control methods. Biological control is a promising approach to reduce plant diseases caused by nematodes. READ MORE
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4. Protein Interaction Studies with Low Molecular Weight Ligands : Applications for Drug Discovery, Basic Research and Diagnostic Tool Design
Abstract : In this thesis, the interactions between different proteins and small ligands were characterized by surface plasmon resonance spectroscopy (SPR) and fluorescence resonance energy transfer (FRET) based assays. For the C-reactive protein (CRP), a new type of artificial binder was identified which allows designing diagnostic assays superior to commonly used standard assays. READ MORE
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5. Polypeptide functionalized gold nanoparticles for bioanalytical applications
Abstract : Detection strategies that allow for simple, rapid, cost efficient and sensitive monitoring of proteins and their interactions with biomolecules are of great importance in drug development and diagnostics. This thesis describes the development of bioanalytical applications based on the tunable self-assembly of gold nanoparticles functionalized with a de novo designed polypeptide. READ MORE