Search for dissertations about: "immune escape mechanism"
Showing result 1 - 5 of 36 swedish dissertations containing the words immune escape mechanism.
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1. Immune cell infiltration and prognosis in colorectal cancer
Abstract : Background: Colorectal cancer (CRC) is globally the second most common form of cancer among women, and third in men. It is also one of the most common causes of cancer-related death in high-income countries. Surgical resection is the basis for curative therapy but still almost half of the patients die from metastatic disease. READ MORE
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2. Mechanisms of immune escape : implications for immunotherapy against cancer
Abstract : Tumor cells can be recognized and killed by cytotoxic T cells specific for certain tumor antigens. Immune mediated selection pressure along with genetic instability of tumor cells result in a growth advantage of tumor cells that acquire a less immunogenic phenotype. READ MORE
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3. Complement evasion strategies of human pathogens - the evolutionary arms race
Abstract : Although the complement system, a pivotal component of innate immunty, is centrally involved in host defense against pathogens, its overactivation or deregulation may excessively amplify inflammation and contribute to immunopathology. Periodontitis, an oral infection-driven chronic inflammatory disease, has been linked with complement disruption by periodontal bacteria, resulting in inflammation and pathogenesis. READ MORE
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4. The effect of human cytomegalovirus on innate immune responses : immune activation and evasion
Abstract : Human cytomegalovirus (HCMV) is a wide-spread virus infecting about 60-90 % of the healthy human population. After a primary infection, the virus establishes life-long latency in its host. READ MORE
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5. Recognition by and escape from CD8+ T cell immune surveillance in cancer bearing hosts
Abstract : CD8+ T cells ( TCD8+ ) can specifically recognize tumor cells through MHC class I molecules associated with peptides that are 8-l0 amino acid residues long. In recent years, a number of tumor-associated antigens, or their epitopes, have been identified and characterized with the advent of new methods in molecular biology and in peptide isolation. READ MORE
