Search for dissertations about: "immune signaling"

Showing result 16 - 20 of 408 swedish dissertations containing the words immune signaling.

  2. 16. Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity

    Author : Angela Molinaro; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin signaling; PI3Ks; PI3K isoform-selective inhibitors;

    Abstract : Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity to these diseases remains largely unresolved. READ MORE

  4. 17. Immune modulation by mesenchymal stem cells

    Author : Ida Rasmusson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mesenchymal stem cells; T cells; cytotoxic T lymphocytes; cytokines; mixed lymphocyte culture; B cells; antibody production; stem cell transplantation; acute graft versus host disease;

    Abstract : Mesenchymal stem cells (MSCs) were discovered as adherent cells in the bone marrow stroma that could form bone and stimulate hematopoiesis. Later, MSCs were shown to be hypoimmunogenic and to suppress proliferation of activated T cells. READ MORE

  5. 18. Innate immune cell response in sepsis

    Author : Yongzhi Wang; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; abdominal sepsis; neutrophil; monocyte; platelet; coagulation; lung;

    Abstract : Leukocyte recruitment is known to be a key feature at sites of inflammation and important in the combat against infectious agents. However, the mechanisms of leukocyte recruitment in the pulmonary microvasculature in response to local and systemic inflammation remain elusive. READ MORE

  6. 19. Studies on caspase signaling in microglia

    Author : Johanna Rodhe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous system and act as the first line of defense against invading pathogens and other types of brain insults. READ MORE

  7. 20. Innate immune responses to Mycobacterium tuberculosis infection : How extracellular traps and trained immunity can restrict bacterial growth

    Author : Clara Braian; Maria Lerm; Olle Stendahl; Parasa Venkata Ramanarao; Nordenfelt Pontus; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, and the cause of 1.5 million deaths in 2018. During a pulmonary TB infection, the bacterium reaches the lungs and is phagocytosed by cells of the innate immune system, primarily macrophages. READ MORE