Search for dissertations about: "immunodeficiency-virus infection"

Showing result 1 - 5 of 85 swedish dissertations containing the words immunodeficiency-virus infection.

  2. 1. Combination chemotherapy for human immunodeficiency virus infection

    Author : Sarah Palmer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The worldwide spread of human immunodeficiency virus (HIV) has spurred the search for effective drugs to combat this deadly virus. The limited effect of monotherapy treatment, in large measure due to the development of drug resistant viral strains, has led to increased emphasis on combination chemotherapy for the treatment of HIV, the focus of this study. READ MORE

  4. 2. Understanding Complex Diseases and Disease Causative Agents : The Machine Learning way

    Author : Zeeshan Khaliq; Jan Komorowski; Steven Bosinger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pathogens; Influenza A viruses; Human immunodeficiency virus; Simian immunodeficiency virus; Pathogenicity; Cancer; long noncoding RNAs; Machine learning; Host specificity; Host-specific signatures; Bioinformatics; Bioinformatik;

    Abstract : Diseases can be caused by foreign agents – pathogens – such as viruses, bacteria and other parasites, entering the body or by an internal malfunction of the body itself. The partial understanding of diseases like cancer and the ones caused by viruses, like the influenza A viruses (IAVs) and the human immunodeficiency virus, means we still do not have an efficient cure or defence against them. READ MORE

  5. 3. Synthesis of inhibitors against the human immunodeficiency virus : diol-based inhibitors of the HIV-1 protase and 4-substituted carbocyclic nucleoside analogues

    Author : Anna Mühlman; David Tanner; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Abstract : The pandemic spread of HIV infection and AIDS has resulted in intensive research designed to develop effective therapeutic agents. Development of inexpensive inhibitors is necessary to allow treatment of HIV infections in the Third World.In the present thesis, the design and synthesis of several inhibitors of the HIV-1 virus are described. READ MORE

  6. 4. Natural killer cells and antibody-mediated effects in human immunodeficiency virus infection

    Author : Susanne Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human immunodeficiency virus (HIV-1) effectively avoids immunologic eradication. Certain characteristics of the virus contribute to this, including the specific targeting of the body s own defense system, the ability to hide in the host cell genome and the vast viral variability. READ MORE

  7. 5. Human immunodeficiency virus type 1 proteinase : regulation of function and catalytic activity

    Author : Laura Goobar-Larsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : HIV-l proteinase activity is a prerequisite for viral replication, and one of the main targets for anti-HlV therapy. Although potent proteinase inhibitors are currently being approved for treatment of AIDS patients, these drugs are unlikely to provide treatment which can give patients a life of normal quality and duration. READ MORE