Search for dissertations about: "immunogenic complex"

Showing result 1 - 5 of 29 swedish dissertations containing the words immunogenic complex.

  2. 1. Limonene Hydroperoxides in Allergic Contact Dermatitis. Radical Formation, Sensitizing Capacity and Immunogenic Complex Formation

    Author : Staffan Johansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; allergic contact dermatitis; contact allergy; immunogenic complex; limonene hydroperoxides; local lymph node assay; patch testing; radicals; sensitizing capacity; skin;

    Abstract : Contact allergy to fragrance compounds is an increasing problem in the western countries today. R-Limonene is one of the most common fragrance compounds; it is used in hygiene products and cosmetics as well as in industrial products such as hand cleansers and degreasers. READ MORE

  4. 2. Arthritogenic and immunogenic properties of modified autoantigens

    Author : Karin Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Post-translational modifications; pH; chlorination; citrullination; CII; CIA; RA;

    Abstract : Rheumatoid arthritis is a chronic inflammatory joint disorder with autoimmune features in which both genetic and environmental factors are potential contributors to the arthritogenic process. In this thesis work we aimed to increase the understanding of early pathogenic events underlying the development of this complex disease by investigating the arthritogenic and immunogenic properties of modified autoantigens in experimental settings as well as in RA patients. READ MORE

  5. 3. Conformational Studies of Biologically Active Peptides

    Author : Björn Walse; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Abstract : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. READ MORE

  6. 4. The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1

    Author : Rille Pullerits; Göteborgs universitet; []
    Keywords : HMGB1; sRAGE; rheumatoid arthritis; inflammation; cytokines;

    Abstract : Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein recently recognised as a pro-inflammatory cytokine which levels are increased in RA patients. READ MORE

  7. 5. The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex

    Author : Jonas Söderholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; NS3; HLA-A2; viral fitness; DNA vaccine;

    Abstract : The hepatitis C virus (HCV) is a blood-borne virus responsible for a major part of liver transplants is the US, and 3% of the population world-wide is infected globally. HCV belongs to the Hepacivirus genus of the Flaviviridae family and is transmitted through infectious blood or blood products. READ MORE