Search for dissertations about: "immunogenicity"
Showing result 1 - 5 of 144 swedish dissertations containing the word immunogenicity.
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1. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
Abstract : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. READ MORE
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2. Pharmacometric Modeling in Rheumatoid Arthritis
Abstract : Biologic therapies have revolutionized the treatment of rheumatoid arthritis, a common chronic inflammatory disease, mainly characterized by the chronic inflammation of the joints. The activity and progression of the disease are highly variable, both between subjects and between the successive assessments for the same subject. READ MORE
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3. Characterization of antibody specificity using peptide array technologies
Abstract : Antibodies play an important role in the natural immune response to invading pathogens. The strong and specific binding to their antigens also make them indispensable tools for research, diagnostics and therapy. READ MORE
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4. Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera
Abstract : Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be found all over the world and often causes cholera in places where access to clean water or proper sanitary facilities are limited or compromised. READ MORE
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5. Methods for Generation and Characterization of Monospecific Antibodies
Abstract : Recent advances in biotechnology have generated possibilities to investigate and measure parts of life previously left for believers to explain. Utilizing the same book of recipes, the genome, our cells produce selections of proteins at a time and thereby niche into a multitude of specialized cell types, tissues and organs comprising our body. READ MORE