Search for dissertations about: "immunoglobulin G replacement therapy"

Found 4 swedish dissertations containing the words immunoglobulin G replacement therapy.

  2. 1. Clinical and immunological aspects of IgG subclass deficiency : Predictors for the need of immunoglobulin replacement therapy

    Author : Per Wågström; Charlotte Dahle; Sofia N. Nyström; Åsa Nilsdotter-Augustinsson; Mats Nilsson; Ola Winqvist; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunoglobulin G subclass deficiency; inflammation; lymphocytes; fatigue; co-morbidity; immunoglobulin G replacement therapy;

    Abstract : Background: Predominantly antibody deficiencies (PAD) are inborn errors of immunity, and associate with increased susceptibility to infections. Life-long immunoglobulin replacement therapy (IgRT) is introduced based on Ig-levels and the frequencies and severity of infections. READ MORE

  4. 2. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

    Author : Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

    Abstract : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. READ MORE

  5. 3. Nasopharynx and mucosa associated lymphatic tissue : studies on mucosal immunity, nasopharyngeal colonization with non-encapsulated non-typable Haemophilus influenzae and local administration of immunoglobulin in the upper respiratory tract

    Author : Karin Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nasopharyngeal colonization with non-encapsulated Haemophilus influenzae (NTHI) frequently occurs in infants and in adults with common variable immunodeficiency (CVID), but is rarely found among healthy adults. In children with recurrent episodes of acute otitis media (RAOM), NTHI is more common than in healthy individuals. READ MORE

  6. 4. Health-related quality of life, treatment satisfaction and clinical aspects of patients with primary antibody deficiency receiving subcutaneous IgG self-infusions at home

    Author : Uwe Nicolay; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with primary antibody deficiencies (PAD) are unable to produce sufficient amounts of antibodies and are therefore susceptible to severe bacterial infections. The standard therapy has been intravenous infusions of immunoglobulin G (IVIG) every 2-4 weeks. READ MORE