Search for dissertations about: "immunohistochemistry of melanoma"

Showing result 1 - 5 of 12 swedish dissertations containing the words immunohistochemistry of melanoma.

2. 1. Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry

   Author : Margrét Agnarsdóttir; Fredrik Ponten; Peter Naredi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; Tumour biology; Tumörbiologi; Pathology; Patologi; Molecular medicine; Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

   Abstract : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. READ MORE

4. 2. Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma

   Author : Iva Johansson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary cutaneous melanoma; chronic sun-damage; chronic sun-damage skin; gene expression profiling; immunohistochemistry; tertiary lymphoid structures;

   Abstract : Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage II. Correct identification of the patients at high risk for progressive disease who will benefit from the treatment is crucial. READ MORE

5. 3. Aspects of Gene Expression Profiling in Disease and Health

   Author : Julia Bergman; Fredrik Pontén; Lars Akslen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; biomarkers; differential diagnostics; immunohistochemistry; transcriptomics; protein profiling; adrenal gland.; Pathology; Patologi;

   Abstract : The aim of this thesis is to in various ways explore protein expression in human normal tissue and in cancer and to apply that knowledge in biomarker discovery.In Paper I the prognostic significance of RNA-binding motif protein 3 (RBM3) is explored in malignant melanoma. READ MORE

6. 4. Antibody-based Profiling of Expression Patterns using Cell and Tissue Microarrays

   Author : Sara Strömberg; Fredrik Ponten; Joakim Lundeberg; Anna Asplund; Stephen Hewitt; Uppsala universitet; []
   Keywords : Pathology; antibody-based proteomics; tissue microarray; cell line; immunohistochemistry; melanocytes; image analysis; biomarker; Patologi;

   Abstract : In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell lines, a cell microarray (CMA) was developed, facilitating antibody-based protein profiling of cell lines using immunohistochemistry (IHC). READ MORE

7. 5. Immunological Studies in Malignant Melanoma : Importance of TNF and the Thioredoxin System

   Author : Anna-Maria Barral; Anders Rosén; R. Kiessling; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Malignant melanoma is a tumor whose incidence is dramatically increasing in persons with light-coloured skin in all parts of the world. Due to its resistance against traditional chemo- and radiotherapy, melanoma has been a favourite target of alternative therapies, in particular those involving immunological mechanisms. READ MORE