Search for dissertations about: "in silico modeling"

Showing result 16 - 20 of 34 swedish dissertations containing the words in silico modeling.

  2. 16. Nitrile Hydratases and Epoxide-Transforming Enzymes : Quantum Chemical Modeling of Reaction Mechanisms and Selectivities

    Author : Kathrin Hopmann; Fahmi Himo; Nigel G. Richards; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

    Abstract : Quantum chemical studies of enzymatic reactions are able to provide detailed insight into mechanisms and catalytic strategies. The energetic feasibility of proposed mechanisms can be established, and new possible reaction pathways can be put forward. READ MORE

  4. 17. Calcium signaling and network activity : mathematical modeling and molecular mechanisms

    Author : Erik Smedler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability is partially explained by its wide temporal and spatial dynamics. READ MORE

  5. 18. Post-translational modifications of myelin oligodendrocyte glycoprotein in CNS autoimmunity

    Author : Andreas Warnecke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmunity towards components of the central nervous system (CNS) is a driving factor of nerve demyelination in Multiple Sclerosis (MS). The etiology of autoimmunity in MS pathogenesis remains elusive, but a combination of genetic predisposition and environmental triggers is theorized to initiate this complex disease. READ MORE

  6. 19. The role of smooth muscle cells in calcification of atherosclerotic plaques

    Author : Till Seime; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but responsible mechanisms and its contribution to the risk of clinical events remain unclear. Formation of highly mineralized extracellular matrix (ECM) leads to progressive aortic valve stenosis (AVS) and has been identified as a surrogate marker for atherosclerotic disease burden. READ MORE

  7. 20. Thermodynamical and structural properties of proteins and their role in food allergy

    Author : Louise Rundqvist; Göran Larsson; Göran Karlsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein folding; NMR; Food allergy; allergen; protein interactions; medicinsk biokemi; Medical Biochemistry;

    Abstract : Proteins are important building blocks of all living organisms. They are composed of a defined sequence of different amino acids, and fold into a specific three-dimensional, ordered structure. The three-dimensional structure largely determines the function of the protein, but protein function always requires motion. READ MORE