Search for dissertations about: "in silico modeling"
Showing result 21 - 25 of 34 swedish dissertations containing the words in silico modeling.
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21. The MHC genes: variation and impact on life-history traits in house sparrwos
Abstract : In birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. READ MORE
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22. Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
Abstract : Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. The association of IRE1 dysregulation with a wide range of human diseases, stimulated research towards the discovery of small organic molecules able to modulate IRE1 signalling, and to potentially be used as novel therapeutics. READ MORE
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23. Design and synthesis of rhodium and iridium bis-η2 diolefin catalysts: : Applications in C–C bond formation and asymmetric catalysis
Abstract : This thesis deals with the design and synthesis of rhodium and iridium bis-η2 diolefin catalysts and their applications in C–C bond formation and asymmetric catalysis.More specifically, the second chapter describes the development of inter- and intramolecular (5+2) cycloadditions catalyzed by cationic iridium(I) complexes that lead to the formation of seven-membered rings in a single step. READ MORE
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24. Preclinical X-ray imaging beyond attenuation contrast
Abstract : Medical imaging is a cornerstone of modern clinical practice. Here, X-ray imaging is the given choice for rapid morphological imaging with excellent spatial resolution, albeit with sensitivity often insufficient for resolving subtle pathological changes to soft tissues. READ MORE
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25. Nutraceuticals based computational medicinal chemistry
Abstract : In recent years, the edible biomedicinal products called nutraceuticals have been becoming more popular among the pharmaceutical industries and the consumers. In the process of developing nutraceuticals, in silico approaches play an important role in structural elucidation, receptor-ligand interactions, drug designing etc. READ MORE