Search for dissertations about: "in situ hybridization"

Showing result 21 - 25 of 297 swedish dissertations containing the words in situ hybridization.

  2. 21. Human antibody repertoires in normal physiology and in autoimmune disease

    Author : Iris F van Dijk Härd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system has to balance the need for a broad protection from infectious agents against the risk of developing autoimmune disease. The elements of the immune system should provide clues about conditions under which physiological autoreactivity may develop into autoaggressive immunity, if analyzed against the background of the immune system in healthy individuals. READ MORE

  4. 22. Neuroprotection and neurogenesis after experimental stroke

    Author : Andreas Arvidsson; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stereology; rat; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; BrdU; immunohistochemistry; in situ hybridization; subventricular zone; striatum; dentate gyrus; neuronal replacement; neuronal survival; Focal cerebral ischemia; glial cell line-derived neurotrophic factor;

    Abstract : In this thesis, two potential endogenous mechanisms for neuronal survival and repair have been investigated in a rat model of stroke, middle cerebral artery occlusion (MCAO): signaling of the GDNF family of neurotrophic factors, and neurogenesis from endogenous progenitor cells. As determined by in situ hybridization for GDNF family ligand and receptor genes, MCAO caused widespread upregulation of both components of the functional GDNF receptor, c-Ret and GFRalpha1, indicating that GDNF may be a survival signal in stroke. READ MORE

  5. 23. Primary osteoarthrosis in guinea pigs

    Author : Edin de Bri; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The course of primary osteoarthrosis (OA) in Hartley guinea pigs, which spontaneously develop OA in their knee joints, was studied by stereology (quantitative morphology). Between 6 and 12 months of age, structural changes similar to those of human OA developed, predominantly in the central (non-meniscus-covered) medial condyle, while the lateral condyle remained unaffected. READ MORE

  6. 24. Detection and Sequencing of Amplified Single Molecules

    Author : Rongqin Ke; Mats Nilsson; Ulf Landegren; Radoje Drmanac; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; padlock probes; proximity ligation assay; rolling circle amplification; circle-to-circle amplification; single molecule detection; amplified single molecules; sequencing; in situ; single cell; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Improved analytical methods provide new opportunities for both biological research and medical applications. This thesis describes several novel molecular techniques for nucleic acid and protein analysis based on detection or sequencing of amplified single molecules (ASMs). READ MORE

  7. 25. Human Beta-microseminoprotein expression, with special reference to gastric mucosa, atrophic corpus gastritis and gastric carcinoids

    Author : Håkan Weiber; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastric carcinoids; atrophic corpus gastritis; stomach; in situ hybridization; immunohistochemistry; radioimmunoassay; chromogranin A; gastrin; Beta-microseminoprotein; mucin; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; Gastro-enterology; Gastroenterologi;

    Abstract : Human Beta-microseminoprotein is a 94 amino acid protein with 10 cysteins present in seminal plasma and on many mucosal surfaces in the body. The function of the protein is unknown. The purpose of this investigation was to study the distribution of Beta-microseminoprotein in the human body, especially in the stomach. READ MORE