Search for dissertations about: "in situ"

Showing result 1 - 5 of 1502 swedish dissertations containing the words in situ.

  1. 1. In situ Sequencing Methods for spatially-resolved transcriptome analysis

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Marco Mignardi; Stockholms universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Padlock probes; rolling circle amplification; in situ sequencing; spatially-resolved transcriptomics; molecular diagnostics; biokemi; Biochemistry;

    Abstract : It is well known that cells in tissues display a large heterogeneity in gene expression due to differences in cell lineage origin and variation in the local environment at different sites in the tissue, a heterogeneity that is difficult to study by analyzing bulk RNA extracts from tissue. Recently, genome-wide transcriptome analysis technologies have enabled the analysis of this variation with single-cell resolution. READ MORE

  2. 2. Visualizing Interacting Biomolecules In Situ

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Irene Weibrecht; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; in situ PLA; padlock probe; rolling circle amplification; flow cytometry; in situ; single cell; single molecule; protein interaction; protein-DNA interaction; posttranslational modification; MEDICINE Morphology; cell biology; pathology Pathology Molecular medicine; MEDICIN Morfologi; cellbiologi; patologi Patologi Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Abstract : Intra- and intercellular information is communicated by posttranslational modifications (PTMs) and protein-protein interactions, transducing information over cell membranes and to the nucleus. A cells capability to respond to stimuli by several highly complex and dynamic signaling networks provides the basis for rapid responses and is fundamental for the cellular collaborations required in a multicellular organism. READ MORE

  3. 3. Neuropeptide Y Receptors in Human, Guinea pig and Chicken Cloning, in vitro Pharmacology and in situ Hybridization

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Holmberg; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; G-protein coupled receptor; neuropeptide Y; neuropeptide Y receptor; ortholog; chicken; guinea pig; mutagenesis; receptor computer modeling; mRNA in situ hybridization; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Neuropeptide Y (NPY) is known to influence a vast number of physiological and behavioral processes such as vasoconstriction, circadian rhythms, feeding, anxiety and memory. Peptides of the NPY family bind to five different cloned G-protein coupled receptor subtypes (Y1, 2, 4-6). READ MORE

  4. 4. Prognosis in carcinoma in situ of the breast

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Fredrik Wärnberg; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Breast carcinoma; ductal carcinoma in situ; lobular carcinoma in situ; prognosis; histopathological grade; p53; c-erbB-2; Ki 67; Bcl-2; hormone receptors; angiogenesis; Kirurgi; MEDICINE Surgery; MEDICIN Kirurgi; Surgery; kirurgi;

    Abstract : The incidence of breast cancer is rising steadily in Sweden and the proportion of carcinoma in situ (CIS) has increased appreciably, most likely due to mammography screening. The aim of this study was twofold: (1) to examine risk factors for subsequent invasive breast carcinoma and breast cancer death after primary ductal carcinoma in situ (DCIS) and (2) to study the biology in the progress between in situ and invasive carcinoma. READ MORE

  5. 5. Diffusion of Radionuclides in Bentonite Clay Laboratory and in sity Studies

    University dissertation from Stockholm : KTH

    Author : Mats Jansson; KTH.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bentonite; montmorillonite; cation; anion; diffusion; sorption; cobalt; caesium; strontium; iodide; pertechnetate; surface diffusion; in situ; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi;

    Abstract : This thesis deals with the diffusion of ions in compactedbentonite clay. Laboratory experiments were performed toexamine in detail different processes that affect thediffusion. To demonstrate that the results obtained from thelaboratory investigations are valid under in situ conditions,two different kinds of in situ experiments were performed. READ MORE