Search for dissertations about: "in vitro bioavailability"

Showing result 1 - 5 of 64 swedish dissertations containing the words in vitro bioavailability.

2. 1. Hazard screening of contaminated sites : bioavailable fractions and biological in vitro tools

   Author : Daniel Ragnvaldsson; Mats Tysklind; Per Leffler; Lars Lövgren; Bengt-Erik Bengtsson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hazard screening; bioavailability; metal pollution; in vitro cytotoxicity; water extraction; CCA; arsenic genotoxicity; genotoxicity; Contaminated soil; Environmental chemistry; Miljökemi;

   Abstract : The environmental bioavailability of contaminants, rather than their total concentrations in the soil compartment play a decisive role for the risks associated with contaminated sites. Various soil constituents and abiotic conditions have strong influence on bioavailability, which may vary substantially between different locations. READ MORE

4. 2. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

   Author : Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

   Abstract : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. READ MORE

5. 3. In Vitro Availability of Iron in High-Tannin Sorghum. Effect of Enzymatic Oxidation of Phenolic Compounds

   Author : Erika Matuschek; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; bioavailability; catechol groups; polyphenols; polyphenol oxidase; iron; in vitro availability; tyrosinase; fruit extracts; sorghum; oxidation; tannins; galloyl groups;

   Abstract : Iron deficiency anemia is the most common nutritional disorder in the world. In low income countries, it is to a large extent caused by low bioavailability of iron in the vegetable diet. Vegetable diets contain large amounts of compounds that inhibit iron absorption, e.g. READ MORE

6. 4. In vitro Bioaccessibility of Carotenes: Influence of microstructure in tomato and carrot as modified by processing

   Author : Cecilia Svelander; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; α-carotene; in vitro bioaccessibility; high-pressure homogenisation; carrot; in vivo bioavailability; Caco-2 cell model; blanching; processing; Lycopene; β-carotene; tomato; microstructure;

   Abstract : Carotenes are a group of fat-soluble pigments in many fruits and vegetables associated with several important biological effects, like protection against the development of some forms of cancer and cardiovascular disease. The carotene bioavailability in plant foods, i.e. READ MORE

7. 5. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

   Author : Ann Tronde; Gerrit Borchard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE