Search for dissertations about: "in vitro developmental neurotoxicity"

Showing result 1 - 5 of 12 swedish dissertations containing the words in vitro developmental neurotoxicity.

  2. 1. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

    Author : Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. READ MORE

  4. 2. Cellular transport and secretion of the cyanobacterial neurotoxin BMAA into milk and egg : Implications for developmental neurotoxicity

    Author : Marie Andersson; Ingvar Brandt; Cynthia de Wit; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; BMAA; beta-N-methylamino-L-alanine; milk; secretion; amino acid transporter; autoradiography; metabolism; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Abstract : The cyanobacterial amino acid β-N-methylamino-L-alanine (BMAA) is a neurotoxin implicated in the etiology of neurodegenerative diseases. Cyanobacteria are cosmopolitan organisms present in various environments. READ MORE

  5. 3. In vitro developmental neurotoxicity of acrylamide

    Author : Kristina Attoff; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The number of children with neurodevelopmental disorders is increasing worldwide which makes it a public concern. Exposure to environmental chemicals has been reported as a source of developmental neurotoxicity. READ MORE

  6. 4. Developmental Neurotoxicity Testing Using In vitro Approaches

    Author : Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

    Abstract : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. READ MORE

  7. 5. Proteomic Characterization of Induced Developmental Neurotoxicity

    Author : Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Abstract : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. READ MORE