Search for dissertations about: "in vitro differentiation"

Showing result 16 - 20 of 534 swedish dissertations containing the words in vitro differentiation.

  2. 16. Chemokines and bone : lessons from in vitro and in vivo studies

    Author : Sara Rosendahl; Pernilla Lundberg; Cecilia Koskinen Holm; Elin Kindstedt; Marie Lagerquist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Bone homeostasis is maintained by the balanced activity of bone-forming osteoblasts and bone-resorbing osteoclasts. Inflammation in the vicinity of bone disturbs the balanced bone remodeling process, which often results in bone loss. READ MORE

  4. 17. Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes

    Author : Radha Thyagarajan; Kristina Lejon; Per-Arne Oldenborg; Susanna Cardell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; B cells; IgE; TACI; BAFF; immunologi; Immunology;

    Abstract : The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. READ MORE

  5. 18. Muscle cell integrins in vitro and in vivo : Identification and characterisation of a novel integrin, α11β1

    Author : Teet Velling; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; integrins; α7 integrin; α11 integrin; embryonic development; muscle; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Integrins are heterodimeric receptors composed of non-covalently associated αand β subunits which have distinct functions on different cell types. α7β1integrin is an important laminin receptor in skeletal muscle. The mRNA andprotein expression patterns of α7A and α7B splice variants during mousedevelopment were studied. READ MORE

  6. 19. On the Role of the Tumor Suppressor p53 in Leukemic Cell Differentiation

    Author : Mats Ehinger; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; p53; Tumor Suppressor Genes; Leukemia; Differentiation; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. READ MORE

  7. 20. Notch Signaling in Human Neuroblastoma Cells

    Author : Marie Stockhausen; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Hes-1; Medicin människa och djur ; Medicine human and vertebrates ; hypoxia; TGF-alpha; EGFR; ERK1 2; Ras MAPK; differentiation; valproic acid; ubiquilin-1; neuroblastoma; Hash-1; Cytologi; onkologi; cancer; cancerology; Cytology; Notch;

    Abstract : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. READ MORE