Search for dissertations about: "in vitro drug sensitivity"

Showing result 16 - 20 of 89 swedish dissertations containing the words in vitro drug sensitivity.

  2. 16. Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro

    Author : Håkan Karlsson; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokine; adhesion molecule; endothelium; lymphocyte metabolism; interleukin 2 receptor; FK506; cyclosporin A; Mikrobiologi; bakteriologi; virologi; mykologi; Immunology; transplantation; serology; Microbiology; bacteriology; mycology; virology; Immunologi; serologi;

    Abstract : In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. READ MORE

  4. 17. In vivo and in vitro models for determination of antiviral activity and resistance

    Author : Ewa Ljungdahl Ståhle; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The AIDS epidemic has been the driving force for the discovery of substances that inhibit the replication of human immunodeficiency virus (HIV). Much interest has earlier focused on a single gene product central to the life cycle of HIV and to all other retroviruses: the reverse transcriptase (RT), the enzyme responsible for synthesis of DNA from viral RNA. READ MORE

  5. 18. Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance

    Author : Maria Isabel Mendes Veiga; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development and spread of drug resistance among malaria parasites. READ MORE

  6. 19. O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma

    Author : Shuhua Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Melanoma; chemotherapy; dacarbazine; drug resistance; O6-methylguanineDNAmethyltransferase; DNA mismatch repair;

    Abstract : Although the survival rate of patients with malignant melanoma has improved, treatment of the disease poses large problems since disseminated melanoma frequently shows primary resistance to chemotherapy. Resistance to chemotherapy is thus a major clinical problem and a cause of failure in the treatment of metastatic malignant melanoma. READ MORE

  7. 20. In Vitro Studies of Factors Potentially Affecting Plasmodium Falciparum Infection : (Heparin and Anti-P. falciparum Immune Responses)

    Author : Asli Kulane; Birthe Högh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Immunology; Immunologi; immunologi; Immunology;

    Abstract : Plasmodium falciparum malaria is considered one of the major infectious diseases in humans, with regard to mortality and morbidity. Growing resistance of malaria to most anti-malaria drugs and of the Anopheles mosquitoes to insecticides have resulted in a global resurgence of the disease. READ MORE