Search for dissertations about: "in vitro drug sensitivity"
Showing result 6 - 10 of 89 swedish dissertations containing the words in vitro drug sensitivity.
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6. In vitro testing of drug sensitivity in tumor cells from effusion
Abstract : Malignant mesothelioma has a mean overall survival of around 1 year and lung adenocarcinoma with pleural spread has a mean overall survival of around 5 months. Both diseases cause fluid accumulation in the pleura, which is drained to alleviate associated symptoms such as shortness of breath. This fluid oft contains exfoliated tumor cells. READ MORE
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7. Chemosensitivity in Breast Cancer
Abstract : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. READ MORE
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8. Drug resistance in acute myeloid leukemia : pharmacokinetic and in vitro studies
Abstract : Chemotherapy has improved clinical outcome in adult acute myeloid leukemia (AML) but still the majority of the patients die of their disease. One important explanation is transport mediated drug resistance resulting in refractory or relapsing disease. P-glycoprotein (Pgp) is located in the membrane and can extrude cytostatic drugs. READ MORE
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9. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications
Abstract : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. READ MORE
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10. Urinary tract infections in primary health care in northern Sweden : epidemiological, bacteriological and clinical aspects
Abstract : The epidemiology of urinary tract infection (UTI) in the population of Vännäs (8 000 inhabitants) was studied during one year. The annual incidence increased from 0.5% in the first decade of life to more than 10% in the age group 90-100 years. READ MORE