Search for dissertations about: "in vitro receptor binding"
Showing result 1 - 5 of 319 swedish dissertations containing the words in vitro receptor binding.
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1. Neuropeptide Y Receptors in Human, Guinea pig and Chicken : Cloning, in vitro Pharmacology and in situ Hybridization
Abstract : Neuropeptide Y (NPY) is known to influence a vast number of physiological and behavioral processes such as vasoconstriction, circadian rhythms, feeding, anxiety and memory. Peptides of the NPY family bind to five different cloned G-protein coupled receptor subtypes (Y1, 2, 4-6). READ MORE
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2. Development of nicotinic receptor ligands for positron emission tomography - from in vitro to in vivo : Binding studies of neuronal nicotinic acetylcholine receptors using different ³H-, ¹1C- and `6Br - labeled ligands
Abstract : Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in central processes, such as cognitive functionand memory, and play a critical role in neuropathological changes in Alzheimer's disease (AD). The in vivocharacterization of nAChRs by positron emission tomography (PET) may increase our understanding of thefunctional implications of these receptors in AD and their early changes during this disease. READ MORE
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3. Creating cell microenvironments in vitro
Abstract : Stem cells have a great potential to bring about advancements in fields like developmental biology, drug discovery, cancer biology and tissue engineering. In order to be able to use stem cells to their full potential, it is important to have control over their behavior. READ MORE
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4. Nuclear receptor corepressor N-CoR : role in transcriptional repression
Abstract : The human body consists of a multitude of cells of varying appearance and function. With a few exceptions they are genetically identical, and the key to their divergence lies in their different specific patterns of gene expression. READ MORE
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5. Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma
Abstract : The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise to a general positron-emitting tracing technique. The methodological part of the present thesis involved the evaluation of the performance of storage phosphor (SP) plates, with tracers labeled with high-energy, short-lived, positron-emitting radionuclides, using homogenized tissue specimens and autoradiography with frozen brain sections. READ MORE