Search for dissertations about: "in vitro screening of drug effects"
Showing result 1 - 5 of 30 swedish dissertations containing the words in vitro screening of drug effects.
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1. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs
Abstract : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. READ MORE
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2. Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
Abstract : Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. READ MORE
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3. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines
Abstract : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. READ MORE
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4. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus
Abstract : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. READ MORE
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5. Transcriptomics and Proteomics Applied to Developmental Toxicology
Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE