Search for dissertations about: "in vitro system"
Showing result 1 - 5 of 1340 swedish dissertations containing the words in vitro system.
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1. On magnesium-modified titanium coatings and magnesium alloys for oral orthopaedic applications : in vitro investigation
Abstract : In dentistry and orthopaedic surgery, research to find and developimproved biomaterials is progressing rapidly.Of specific interest is to accelerate bone formation around theimplant surface, which could improve the reliability of the implanteven in patients with compromised situations. READ MORE
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2. Development of Methods for Assessing Unbound Drug Exposure in the Brain : In vivo, in vitro and in silico
Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE
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3. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment
Abstract : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. READ MORE
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4. Mechanisms of muscarinic feedback regulation of acetylcholine release in rat hippocampus : an in vitro study
Abstract : The present study on dilute suspensions of synaptosomes from rat hippocampus yields evidence that feedback regulation of acetylcholine release in this preparation is exerted by a muscarinic autoreceptor localized on the cholinergic nerve ending itself.A possible model for the sequence of events which may take place at the cholinergic nerve ending is presented. READ MORE
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5. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility
Abstract : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. READ MORE