Search for dissertations about: "in vitro target"

Showing result 1 - 5 of 682 swedish dissertations containing the words in vitro target.

  1. 1. Connective tissue contraction in wound healing : An experimental study in vivo and in vitro

    Author : M. Reza Ghassemifar; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Contraction of connective tissue is an important part of tissue repair that reduces the wound space and helps to decrease the formation of scar tissue, both of which are needed to restore tissue integrity. In the present study, certain cellular mechanisms that are active during connective tissue contraction were assessed and the influence of transforming growth factor-. READ MORE

  2. 2. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

    Author : Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Abstract : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. READ MORE

  3. 3. Chemosensitivity in Breast Cancer

    Author : Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
    Keywords : Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

    Abstract : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. READ MORE

  4. 4. Hazard screening of contaminated sites : bioavailable fractions and biological in vitro tools

    Author : Daniel Ragnvaldsson; Mats Tysklind; Per Leffler; Lars Lövgren; Bengt-Erik Bengtsson; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Hazard screening; bioavailability; metal pollution; in vitro cytotoxicity; water extraction; CCA; arsenic genotoxicity; genotoxicity; Contaminated soil; Environmental chemistry; Miljökemi;

    Abstract : The environmental bioavailability of contaminants, rather than their total concentrations in the soil compartment play a decisive role for the risks associated with contaminated sites. Various soil constituents and abiotic conditions have strong influence on bioavailability, which may vary substantially between different locations. READ MORE

  5. 5. Eosinophil Inflammation in Allergic Disease : Clinical and experimental studies in allergic asthma and allergic rhinitis

    Author : Mary Kämpe; Marie Carlson; Christer Janson; Gunnemar Stålenheim; Magnus Sköld; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergic asthma; allergic rhinitis; eosinophils; pollen season; bronchial challenge; nasal challenge eosinophil degranulation; PI3K signalling; Allergology; Allergologi; Lung Medicine; Lungmedicin; Lung Medicine; Lungmedicin;

    Abstract : Allergic diseases are chronic inflammatory conditions, characterised by eosinophil inflammation systemically and in target organs, where cytotoxic granule proteins are responsible for tissue injury. Allergic rhinitis is known to be a risk factor for the development of asthma, yet not all with rhinitis develop asthma. READ MORE