Search for dissertations about: "in vitro target"

Showing result 6 - 10 of 700 swedish dissertations containing the words in vitro target.

  2. 6. In Vitro Drug Sensitivity and Apoptosis in Chronic Lymphocytic Leukemia

    Author : Maria Norberg; Richard Rosenquist; Anna Åleskog; Elin Lindhagen; Gerard Tobin; Per-Ola Andersson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; in vitro drug sensitivity; apoptosis; prognostic markers; Clinical genetics; Klinisk genetik; Haematology; Hematologi; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; MEDICINE; MEDICIN; Medical genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap; Clinical Genetics; Klinisk genetik; Molekylär genetik; Molecular Genetics; Medical Genetics; Medicinsk genetik; Molekylär medicin; Molecular Medicine;

    Abstract : Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy displaying varying clinical outcome, where molecular markers today can divide patients into prognostic subgroups. Despite the introduction of new agents for treatment, remissions are usually not sustained in CLL and resistance towards treatment can partly be explained by aberrant apoptosis. READ MORE

  4. 7. Myc-induced Lymphomagenesis : In vivo assessment of downstream pathways

    Author : Sara Rimpi; Jonas Nilsson; Juha Klefström; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Myc; lymphomagenesis; Aurora kinases; polyamine; glycolysis; targeting; mouse models of cancer; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Myc oncogenes encode transcription factors that bind to E-box sequences in DNA, driving the expression of a large number of target genes and are deregulated in approximately 70% of human cancers. Deregulated Myc expression cause enhanced proliferation (which is counteracted by apoptosis), angiogenesis and cancer. READ MORE

  5. 8. S100A9 in inflammatory disease: a potential target for amelioration

    Author : Sahar Tahvili; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Quinoline-3-carboxamide; Myeloid cell; Type 1 diabetes; Cancer; S100A9;

    Abstract : The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. READ MORE

  6. 9. Applications of human skin in vitro

    Author : Susanna Lönnqvist; Gunnar Kratz; Magnus Berggren; Jyrki Vuola; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Chronic wounds are a substantial problem in today’s health care and place significant strains on the patient. Successful modelling of the wound healing process is pivotal for the advancement of wound treatment research. Wound healing is a dynamic and multifactorial process involving all constituents of the skin. READ MORE

  7. 10. Identification and characterisation of chitin and cellulose synthases in oomycetes : New tools for biochemical studies and structure determination

    Author : Stefan Klinter; Vincent Bulone; Lauren S. McKee; Mirjam Czjzek; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biochemical characterisation; cellulose synthase; chitin synthase; in vitro activity assay; microtubule-interacting and trafficking domain; nanoparticle; oomycetes; phylogenetic analysis; yeast engineering; biokemisk karakterisering; cellulosasyntas; kitinsyntas; in vitro aktivitetsanalys; mikrotubulus-interagerande och -trafikerande domän; nanopartikel; oomyceter; fylogenetisk analys; jäst proteinteknik; Bioteknologi; Biotechnology;

    Abstract : Despite resembling ‘true’ fungi in terms of morphological features, oo­mycetes form a distinct eukaryotic lineage of filamentous microorganisms that belongs to the stramenopiles, a group of protists also comprising the closely-related brown algae and diatoms. Many oomycetes are devastating pathogens of plants and animals, globally causing significant economic los­ses in the agriculture and aquaculture industries, and posing considerable environmental damage to natural ecosystems. READ MORE