Search for dissertations about: "in vivo function"

Showing result 1 - 5 of 1193 swedish dissertations containing the words in vivo function.

2. 1. The Role of Microvascular Pericytes in the Generation of Pro-fibrotic Connective Tissue Cells : Investigations in vitro and in Reactive Tissues in vivo

   Author : Jakob Karén; Christian Sundberg; Gunilla Westergren-Thorsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pericyte fibroblast differentiation fibrosis; Biochemistry; Biokemi; Microbiology; Mikrobiologi; Cell biology; Cellbiologi; Medical Biochemistry; Medicinsk biokemi; Cellforskning; Cell Research; Mikrobiologi; Microbiology;

   Abstract : Pericytes are cells of mesenchymal origin located on the abluminal side, juxtapositioned to the endothelial cells in capillaries, venules and small arterioles. They are important for maintaining vessel integrity in resting tissues as well as the formation and stabilization of new vessels. READ MORE

4. 2. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro

   Author : Sara Stridh; Peter Hansell; Mats Rundgren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

   Abstract : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. READ MORE

5. 3. Stuck in mind : the role of catastrophizing in pain

   Author : Ida K. Flink; Steven Linton; Johan Vlaeyen; Örebro universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; catastrophizing; pain; fear avoidance; problem solving; Psykologi; Psychology;

   Abstract : Pain catastrophizing emerges in the literature as one of the most important psychological determinants of both pain itself and the negative outcomes commonly associated with it. However, despite decades of research confirming the impact of catastrophizing, there are still areas that remain unexplored or in which the surface has only been scratched. READ MORE

6. 4. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation

   Author : Adriane Guillaumin; Åsa Wallén-Mackenzie; Konstantinos Meletis; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Subthalamic nucleus; optogenetics; basal ganglia; locomotion; Parkinson s disease; aversion; Neuroscience; Neurovetenskap;

   Abstract : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. READ MORE

7. 5. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

   Author : Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

   Abstract : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. READ MORE