Search for dissertations about: "in-line cleavage"

Showing result 1 - 5 of 7 swedish dissertations containing the words in-line cleavage.

  2. 1. Cationic Interactions with Nucleic Acids With Focus on Anticancer Active Platinum(II) Complexes

    Author : Åse Sykfont Snygg; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; in-line cleavage; Cisplatin; oxaliplatin; circular dichroism; DENSPM; polyamines; siRNA; pseudoknot; RNA; thermal melting; anticancer active Pt II complex; DNA;

    Abstract : It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the ionic environment surrounding the polymer. READ MORE

  4. 2. Does acetylcholin play a role in mitosis of V79 Chinese hamster cells?

    Author : Cecilia Söderpalm-Berndes; Stephen M Wolniak; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; toxikologisk genetik; Genetic Toxicology;

    Abstract : The first stages of mitosis are governed by a cascade of phosphorylations brought about by the universal MPF kinase complex. From a regulatory point of view, less is known about late mitotic events. READ MORE

  5. 3. The importance of terrestrial carbon in plankton food webs

    Author : Cesar Bolivar Daniel; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ecology; lakes; carbon; zooplankton; Spumella elongata; Poterioochromonas malhamensis; flagellates; bacteria; stable isotopes; photochemistry; autochthonous; DOC; allochthonous; plankton; Ekologi; Hydrobiology; marine biology; aquatic ecology; limnology; Marinbiologi; limnologi; akvatisk ekologi;

    Abstract : Allochthonous substances, i.e. produced in terrestrial ecosystems, are known to fuel bacterial production in humic lakes. I observed that allochthonous carbon subsidizes bacteria even at high levels of phytoplankton biomass. READ MORE

  6. 4. Autoproteolysis accelerated by conformational strain - a novel biochemical mechanism

    Author : Denny Johansson; Göteborgs universitet; []
    Keywords : SEA domain; autoproteolysis; MUC1; conformational strain; protein folding;

    Abstract : Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membrane-associated mucins that constitute a part of the protective mucus barrier lining epithelial cells. READ MORE

  7. 5. Mechanistic insights into dinuclear zinc enzymes from density functional theory studies

    Author : Rong-Zhen Liao; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemistry; Kemi;

    Abstract : In this thesis, quantum chemical methods have been used to shed light on the reaction mechanisms of several dinuclear zinc enzymes. The enzymes studied are involved in the hydrolysis of phosphates, amides, and carboxylic esters, namely RNase Z, Dihydroorotase (DHO), and N-acyl homoserine lactone hydrolase (AHL lactonase). READ MORE