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Showing result 11 - 15 of 196 swedish dissertations matching the above criteria.

  2. 11. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Author : Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Abstract : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. READ MORE

  4. 12. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    Author : Limin Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE

  5. 13. Development and evaluation of an independent system for absorbed dose calculations in radiotherapy

    Author : Stefan Johnsson; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medicinsk instrumentering; tomografi; radiologi; Klinisk fysiologi; tomography; medical instrumentation; radiology; Clinical physics; cancer; Cytologi; onkologi; cancerology; oncology; Cytology; PDA; mini-phantom; in-air equivalence; primary kerma; transmission measurement; stopping power ratio; entrance dose; beam quality; quality control; error prevention; monitor unit calculation; radiation therapy; dose calculation;

    Abstract : The aim of this work was to develop, implement and evaluate an independent system with which to calculate the absorbed dose, delivered by high-energy X-ray beams, to the prescription point and the depth of dose maximum. The introduction of such a system in the clinical routine may help ensure high-quality treatment and avoidance of errors which may jeopardise the clinical outcome of the treatment (i. READ MORE

  6. 14. Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes

    Author : Mozhgan Dorkhan; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; insulin secretion; glucagon test; insulin resistance; insulin glargine; insulin tolerance test; thiazolidinediones; natriuretic peptides; adiponectin; thyroid associated ophthalmopathy; proinsulin;

    Abstract : Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. READ MORE

  7. 15. Development of an Interactive e-Learning Management System (e-LMS) for Tanzanian Secondary Schools

    Author : Ellen Kalinga; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; e-learning; UML; object oriented system; e-LMS; model driven architecture; participatory action research; web technmologies; secondary schools Tanzania;

    Abstract : e-learning, as defined to be the use of information and communications technology (ICT) for supporting the educational processes, has motivated Tanzania to apply ICT in its education system. Tanzania secondary schools in rural areas are geographically and socially isolated. READ MORE