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Showing result 16 - 20 of 196 swedish dissertations matching the above criteria.

  2. 16. Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo

    Author : Hamdiye Erdal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. READ MORE

  4. 17. Externally assessed psychosocial work characteristics : a methodological approach to explore how work characteristics are created, related to self-reports and to mental illness

    Author : Kerstin Waldenström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Psychosocial work characteristics; exposure assessment; overreporting; psychological well-being; anxiety; depression; work organisation; action strategies; action theory;

    Abstract : The general aim of this thesis was to add knowledge to the area of measurement issues of psychosocial work characteristics and job design by using a more objective methodological approach. Expert assessments were made through direct observations and interviews and are a theory guided nonemotional description that is independent of the specific individuals social or cultural frame of reference. READ MORE

  5. 18. Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene

    Author : Maria Backlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AhR; omeprazole; primaquine; CYP1A1; ligand-independent activation; ligandbinding domain; protein tyrosine kinase; c-src kinase;

    Abstract : The aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that is responsible for the activation of several response genes, of which the best characterised is the CYP1A1 gene. The prototype high affinity ligand for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). READ MORE

  6. 19. Peroxisome proliferator-activated receptor delta : regulation of skeletal muscle metabolism

    Author : David Kitz Krämer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Peroxisome Proliferator-Activated Receptor PPAR 4 insulin sensitivity; insulin action; human skeletal muscle; primary cultured muscle cells; lipid-metabolism; glucose metabolism; AMP activated protein kinase AMPK ; Type 2 Diabetes Mellitus;

    Abstract : Peroxisome Proliferator-Activated Receptor (PPAR) δ is a nuclear transcription factor which has been implicated in the regulation of lipid metabolism in skeletal muscle. In addition to the postural and locomotive functions of skeletal muscle, this organ has a major impact role on whole body metabolism. READ MORE

  7. 20. Opening the black box of material criticality : heterogeneity and interrelations of companies within and across industrial sectors

    Author : Yulia Lapko; Cali Nuur; Paolo Trucco; Aristides Matopoulos; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Critical materials; Identification; Mitigation; Company; Supply chain; Inter-sectoral competition; Buyer-supplier power relations; Industriell ekonomi och organisation; Industrial Economics and Management;

    Abstract : The concept of ‘material criticality’ has been introduced to examine availability and accessibility of natural resources that underlie industrial competitiveness and deployment of strategic technologies, such as electric mobility or wind turbines. The academic and policy discourse conceptualised material criticality rather as a black box, assuming industrial sectors to be monolithic, homogeneous and independent entities, neglecting complexity of the company dimension. READ MORE