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Showing result 21 - 25 of 196 swedish dissertations matching the above criteria.

  2. 21. Admissible Heuristics for Automated Planning

    Author : Patrik Haslum; Patrick Doherty; Derek Long; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; AI planning; optimal planning; temporal planning; heuristic search; Computer science; Datalogi;

    Abstract : The problem of domain-independent automated planning has been a topic of research in Artificial Intelligence since the very beginnings of the field. Due to the desire not to rely on vast quantities of problem specific knowledge, the most widely adopted approach to automated planning is search. READ MORE

  4. 22. Roles of hematopoietin and cytokine tyrosine kinase receptors in early lymphopoiesis

    Author : Christina Jensen; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL -7; FLT3 Ligand; cytokines; lymphopoiesis; hematopoiesis; TSLP; apoptosis;

    Abstract : Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain unresolved. Among other, while the action of interleukin (IL)-7 in alpha beta T cell development in mouse seems to be largely mediated through permissive survival signaling, the possible permissive role of IL-7 in early B cell development is disputed. READ MORE

  5. 23. Functional dualism of antimicrobial host defence peptides

    Author : Åse Björstad; Göteborgs universitet; []
    Keywords : antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Abstract : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. READ MORE

  6. 24. Kinase cascades in the regulation of glucose homeostasis

    Author : Tatiana L Steiler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; insulin resistance; T2DM; hyperglycemia; high fat diet; glucose transport; PI3K-; MAPK- and AMPK-signaling pathways; AMPKgamma3;

    Abstract : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. READ MORE

  7. 25. On Cholecystokinin and Phospholipase A2 in Insulin Secretion - an Experimental Study With Reference to the Development of Diabetes

    Author : Erik Simonsson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin Resistance; Islet; Beta-cell; Insulin Secretion; Ca2 -Dependency; Intracellular Signalling; Phospholipase A2; Cholecystokinin; Non-glucose Secretagogues; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : In view of unsolved issues regarding cellular events underlying the adaptation of insulin secretion to insulin resistance, together with the observation that insulin secretion induced by the gastrointestinal hormone and neuropeptide cholecystokinin (CCK) is not solely explained by phospholipase C-protein kinase C (PLC-PKC) pathway activation, this study aimed at delineate mechanisms responsible for the hyperinsulinemia in insulin resistance, with particular attention paid to the action of glucose vs. non-glucose secretagogues, such as CCK. READ MORE