Search for dissertations about: "individual response"

Showing result 21 - 25 of 1006 swedish dissertations containing the words individual response.

  2. 21. Response of glaciers to climate change : Mass balance sensitivity, sea level rise and runoff

    Author : Mattias de Woul; Regine Hock; Peter Jansson; Margareta Hansson; Roger J. Braithwaite; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glacier; mass balance modelling; mass balance sensitivity; sea level rise; glacial runoff; Hofsjökull; Storglaciären; Physical geography; Naturgeografi; Physical Geography; naturgeografi;

    Abstract : The purpose of this study is to enhance our understanding of the response of glaciers to climate change. Global sea level is affected by changes in glacier ice volume, and melt-water from glaciers is a principal water source in many regions. READ MORE

  4. 22. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

    Author : Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). READ MORE

  5. 23. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Author : Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. READ MORE

  6. 24. Colour Response in Drying of Nordic Hardwoods

    Author : Stefan Stenudd; Thomas Thörnqvist; Timo Kärki; Linnéuniversitetet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; beech; Betula pendula; birch; CIELAB; discolouration; drying; Fagus sylvatica; log storage; oak; press drying; wood colour; Quercus robur; Forestry and Wood Technology; Skog och träteknik;

    Abstract : Colour and appearance of hardwood are of great importance for the interiorand furniture industry. The widespread use of transparent surface treatmentand a fashion that prescribe light colour on many species, means that deviationfrom the ideal have considerable impact on the industrial operations. READ MORE

  7. 25. Factors modifying cellular response to ionizing radiation

    Author : Lei Cheng; Andrzej Wojcik; Siamak Haghdoost; Lovisa Lundholm; Penelope A. Jeggo; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; DNA damage; gene expression; alpha particles; X-rays; mixed beams; gamma rays; hypothermia; dose rate.; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Many physical factors influence the biological effect of exposure to ionizing radiation, including radiation quality, dose rate and temperature. This thesis focuses on how these factors influence the outcome of exposure and the mechanisms behind the cellular response. READ MORE