Search for dissertations about: "indoleamine 2"

Showing result 1 - 5 of 15 swedish dissertations containing the words indoleamine 2.

  2. 1. Molecular mechanisms behind the liver-induced acceptance of renal grafts in highly sensitized patients

    Author : Madeleine Ingelsten; Göteborgs universitet; []
    Keywords : kidney transplantation; liver tolerance; HLA antibodies; dendritic cells; indoleamine 2; 3-dioxygenase; IL-10; natural killer cells;

    Abstract : Preformed antibodies directed at donor HLA are considered an absolute contraindication for kidney transplantation, because of the high risk of rejection. Thus, patients with high levels of HLA antibodies have little chance of receiving a kidney transplant. READ MORE

  4. 2. Immune tolerance by interferon-alpha in experimental arthritis

    Author : Jaya Prakash Chalise; Mattias Magnusson; Thomas Skogh; Richard O Williams; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Type I Interferons (mainly IFN-α & IFN-β) belong to a family of cytokines that possess strong antiviral and immunomodulatory properties. Pro- and/or anti-inflammatory effects of type I IFN have been observed in infectious diseases and several autoimmune diseases including SLE, MS, RA and experimental models thereof, but what defines either outcome is largely obscure. READ MORE

  5. 3. Immunoregulatory effects of placenta-derived decidual stromal cells

    Author : Tom Erkers; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Decidual stromal cells (DSCs) play a pivotal role in feto-maternal tolerance to prevent rejection of the fetus during pregnancy. This provides a rationale for immunomodulatory stromal cells from the placenta being isolated and used as cellular therapy for inflammatory conditions following hematopoietic stem cell transplantation (HSCT). READ MORE

  6. 4. The interplay between lipoproteins, immunity and tryptophan metabolism in atherosclerosis

    Author : Konstantinos A Polyzos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis is initiated by the infiltration and accumulation of low-density lipoprotein (LDL) cholesterol in the vascular wall, which activates the innate and adaptive arm of immunity, thereby causing chronic vascular inflammation. READ MORE

  7. 5. Crosstalk of human mesenchymal stromal cells with the cellular components of the immune system

    Author : Regina Jitschin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Using the potential of immune regulatory cell populations for cellular therapy constitutes an attractive tool to obliterate imbalances of immune responses in inflammatory disorders. In this context, adoptive transfer of mesenchymal stromal cells (MSCs) represents a relatively novel approach and its impact on the immune system has not been completely clarified. READ MORE