Search for dissertations about: "indoleamine"

Showing result 1 - 5 of 15 swedish dissertations containing the word indoleamine.

  2. 1. Molecular mechanisms behind the liver-induced acceptance of renal grafts in highly sensitized patients

    Author : Madeleine Ingelsten; Göteborgs universitet; []
    Keywords : kidney transplantation; liver tolerance; HLA antibodies; dendritic cells; indoleamine 2; 3-dioxygenase; IL-10; natural killer cells;

    Abstract : Preformed antibodies directed at donor HLA are considered an absolute contraindication for kidney transplantation, because of the high risk of rejection. Thus, patients with high levels of HLA antibodies have little chance of receiving a kidney transplant. READ MORE

  4. 2. Immunometabolic regulation of atherosclerosis

    Author : Martin Berg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ischaemic heart disease and stroke are the most common causes of death in the world, both diseases being manifestations of atherosclerotic cardiovascular disease. Atherosclerosis is a slow process initialized by the retention and accumulation of cholesterol rich lipoproteins in the innermost layer of the artery wall. READ MORE

  5. 3. IDO gene expression induction by DNA methylation inhibitors

    Author : Hua Liu; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The aim was to study the effect of DNA methylation of CpG motifs in cancer cells and immune cells by use of the DNA methyltransferas (DNMT) inhibitor zebularine. In cancer cells it is known that genes can be silenced by chromosomal deletion(s). It is also known that genes can be silenced by DNA methylation or expression of micro-RNA. READ MORE

  6. 4. Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma

    Author : Soudabeh Rad Pour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with a poor prognosis. READ MORE

  7. 5. Crosstalk of human mesenchymal stromal cells with the cellular components of the immune system

    Author : Regina Jitschin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Using the potential of immune regulatory cell populations for cellular therapy constitutes an attractive tool to obliterate imbalances of immune responses in inflammatory disorders. In this context, adoptive transfer of mesenchymal stromal cells (MSCs) represents a relatively novel approach and its impact on the immune system has not been completely clarified. READ MORE