Search for dissertations about: "inducible transcription factors"

Showing result 1 - 5 of 96 swedish dissertations containing the words inducible transcription factors.

2. 1. Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells

   Author : Tobias Löfstedt; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Biomedicinska vetenskaper; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; Biomedical sciences; MXI1; ID2; differentiation; HIF; hypoxia; transcription; cancer; neuroblastoma; Cytologi; onkologi;

   Abstract : Cancer is a major cause of human morbidity and mortality, and the risk of developing cancer is about one in three life times. Neuroblastoma is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. READ MORE

4. 2. Hox transcription factors in hematopoiesis

   Author : Jon Mar Björnsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; extracellulära vätskor; Haematology; hematopoies; tet; Hox; cre lox;

   Abstract : Hematopoiesis is a lifelong, dynamic process in which a small number of pluripotent hematopoietic stem cells (HSC) residing in the bone marrow (BM) give rise to billions of mature blood cells of both myeloid and lymphoid origin each day. This enormous capacity of HSC has been utilized in BM transplantations for 4 decades and is also very important for future gene therapy. READ MORE

5. 3. The Role of Hox Transcription Factors in the Regulation of Hematopoiesis

   Author : Mattias Magnusson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; Haematology; Hox genes; Knockout; Hematopoietic stem cells; Hematopoiesis; Transcription Factor;

   Abstract : Hematopoiesis is a lifelong, dynamic process, originating from a low number of hematopoietic stem cells (HSCs) residing in the adult bone marrow with the ability to self-renew and generate all blood lineages throughout life. Recent findings have demonstrated that the Homeobox (Hox) transcription factors are important regulators of both normal and malignant hematopoiesis, controlling proliferation, differentiation and self-renewal of hematopoietic cells at different levels of the hematopoietic hierarchy. READ MORE

6. 4. Involvement of Rel and GATA transcription factors in the regulation of antimicrobial peptide gene expression in Drosophila melanogaster

   Author : Ulla-Maja Petersen; Himadri Pakrasi; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular Biology; molekylärbiologi;

   Abstract : Insects posses a powerful immune system related to the innate immune reactions present in vertebrates. When insects are infected by bacteria or other microorganisms, a vast production of different antimicrobial peptides is activated. The expression of antimicrobial peptides is regulated at the level of transcription. READ MORE

7. 5. Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma

   Author : Arash Hamidian; Avdelningen för translationell cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2α; enChIP; ESRRA; mTORC2; IGF-II; Hypoxia; Cancer; PI3K; Transcription; Neuroblastoma;

   Abstract : Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of high-risk children. READ MORE