Search for dissertations about: "infektionssjukdomar Infektionssjukdomar"

Showing result 6 - 10 of 222 swedish dissertations containing the words infektionssjukdomar Infektionssjukdomar.

  2. 6. Tamiflu® - Use It and Lose It?

    Author : Josef D. Järhult; Björn Olsen; Hanna Söderström; Jonas Waldenström; Robert G. Webster; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; oseltamivir; Tamiflu; resistance development; H274Y; environment; pharmaceuticals; mallard; dabbling duck; avian influenza; influensa; resistensutveckling; miljö; läkemedel; gräsand; Infektionssjukdomar; Infectious Diseases;

    Abstract : Influenza A viruses cause seasonal and pandemic outbreaks that range from mild infections to the disastrous Spanish Flu. Resistance to neuraminidase inhibitors (NAIs) is a growing problem as these drugs constitute a vital part of treatment strategies and pandemic preparedness plans worldwide. Oseltamivir (Tamiflu®) is the mostly used NAI. READ MORE

  4. 7. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections

    Author : Matti Karvanen; Otto Cars; Lena E Friberg; Vincent H Tam; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colistin; CMS; Pharmacology; Pharmacokinetics; PKPD; Antibiotics; Combination therapy; Pharmacometrics; Dosing regimens; Antibiotic resistance; Infectious Diseases; Infektionssjukdomar;

    Abstract : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. READ MORE

  5. 8. In vitro Pharmacodynamics of Antifungal Agents in the Treatment of Candida Infections

    Author : Anders Lignell; Jan Sjölin; Elisabeth Löwdin; Mats Kalin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amphotericin B; antagonism; Candida; human serum; inhibition; interaction; in vitro; kinetic model; pharmacodynamics; pharmacokinetics; posaconazole; protein binding; voriconazole; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

    Abstract : Pharmacodynamic studies are important for the optimal use of antimicrobial agents. Combination antifungal therapy may be one method to improve outcome in invasive Candida infections. READ MORE

  6. 9. Impact of the inflammatory response on specific immunity in neurosurgical patients

    Author : Anna Ljunghill Hedberg; Jan Sjölin; Karlis Pauksen; Lars Hagberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T-cell-dependent vaccine; T-cell-independent vaccine; CNS injury-induced immune deficiency syndrome; pneumococcal conjugate vaccine; pneumococcal polysaccharide vaccine; posttraumatic meningitis.; Medicinsk vetenskap; Medical Science; Infektionssjukdomar; Infectious Diseases;

    Abstract : Vaccination with a T-cell-dependent pneumococcal conjugate vaccine (PCV) followed by a T-cell-independent pneumococcal polysaccharide vaccine (PPSV) is recommended after basilar skull fracture to reduce the risk of meningitis. The optimal time frame for vaccination has not yet been established and varies widely in practice. READ MORE

  7. 10. Arsenic Influences Virus Replication in Experimental Coxsackievirus B3 Infection

    Author : Ylva Molin; Nils-Gunnar Ilbäck; Eva Hjelm; Göran Friman; Jonas Blomberg; Gunnar Nordberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coxsackievirus B3; trace elements; arsenic; selenium; virology; IFN-γ; NFκB; Infectious diseases; Infektionssjukdomar; Infectious Diseases; Infektionssjukdomar;

    Abstract : Trace elements are essential for the host defence against infections, and during common infections, the balance of trace elements is changed in serum and tissues. Supplementation with selenium (Se), an essential trace element, is known to decrease the severity of coxsackievirus B3 (CVB3) infection in mice. READ MORE