Search for dissertations about: "inflammasome"

Showing result 1 - 5 of 50 swedish dissertations containing the word inflammasome.

  2. 1. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections

    Author : Berhane Asfaw Idosa; Eva Särndahl; Anne Kelly; Bo Söderquist; Alexander Persson; Johan Bylund; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteremia; Cytokines; Gene variants; Inflammasome; Inflammation; Innate immunity; Neutrophils; Meningitis; Neisseria meningitidis; Biomedicin; Biomedicine;

    Abstract : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. READ MORE

  4. 2. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

    Author : Deepti Verma; Peter Söderkvist; Ulf Andersson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; Medical genetics; Medicinsk genetik;

    Abstract : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. READ MORE

  5. 3. On causes and regulation of anti-viral defence in asthma and COPD

    Author : Mandy Menzel; Respiratorisk immunofarmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; ; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress; asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress;

    Abstract : Rhinovirus infection is a main trigger of asthma and COPD exacerbations. dsRNA, a viral replication intermediate, is sensed by pattern recognition receptors in the airway epithelium leading to down-stream induction of anti-viral interferons. READ MORE

  6. 4. Regulation of inflammasomes by host- and pathogen-derived factors

    Author : Dora Hancz; Värd-patogeninteraktioner; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate Immunity; pattern recognition receptors; inflammasome; Streptococcus pyogenes;

    Abstract : The term inflammasome was first coined in 2002 and describes an intracellular multiprotein complex mediating inflammation by inducing the release of pro-inflammatory cytokines (IL-1β and IL-18) and a lytic form of cell death called pyroptosis. Since then, an impressive amount of research has revealed many details about the mechanisms of inflammasome activation as well as the functional relevance of inflammasome activation in different contexts. READ MORE

  7. 5. Innate immunity in human atherosclerosis and myocardial infarction : Role of CARD8 and NLRP3

    Author : Geena Paramel Varghese; Karin Fransén; Allan Sirsjö; Liza Ljungberg; Johan Frostegård; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Inflammasome; NLRP3; CARD8; Myocardial infarction; Endothelial cells; Polymorphism; IL-1β; Cytokines; Innate immunity; Biomedicin; Biomedicine;

    Abstract : Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). READ MORE