Search for dissertations about: "inflammasome"
Showing result 21 - 25 of 50 swedish dissertations containing the word inflammasome.
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21. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis
Abstract : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. READ MORE
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22. Immunopsychiatry from a transdiagnostic perspective : the immunometabolic interplay
Abstract : Background/Objective: Psychiatric disorders are common and they significantly impact quality of life. It has been proposed that inflammatory processescontribute to the emergence of psychiatric disorders. In addition to inflammation, disturbances in metabolic pathways have been seen in individuals with various psychiatric disorders. READ MORE
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23. Colorectal cancer and surgery : Insights into insulin resistance and inflammatory markers
Abstract : The art of surgery has progressively extended from the realm of anatomy to encompass physiology and beyond, in search of further refinement and optimal recovery. Integral to this is a deeper understanding of the body’s essential metabolic and inflammatory responses to surgical trauma. READ MORE
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24. Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro
Abstract : The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens. Since the development of new cancer treatments are expensive and time consuming, repurposing drugs is preferable when possible. READ MORE
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25. Innate immune modulation in atherosclerosis : with focus on ApoB100 derived danger associated signal 1 (ApoBDS-1)
Abstract : Elevated level of LDL is the most important risk factor for atherosclerosis. ApoB100 is the only unexchangeable protein in LDL particle. Recent reports have shown that native peptides of ApoB100 trigger activation of adaptive immune responses. Whether ApoB100 can activate innate immune response is unknown. READ MORE