Search for dissertations about: "inflammatory cell death"

Showing result 11 - 15 of 236 swedish dissertations containing the words inflammatory cell death.

  2. 11. Inflammatory cell death of human macrophages induced by Aggregatibacter actinomycetemcomitans leukotoxin

    Author : Peyman Kelk; Anders Johansson; Charels A Dinarello; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregatibacter actinomycetemcomitans; leukotoxin; IL-1β; caspase-1; inflammatory cell death; pyroptosis; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Abstract : Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. READ MORE

  4. 12. Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88

    Author : Malin Sundquist; Göteborgs universitet; []
    Keywords : Dendritic cells; Costimulatory molecules; Bacterial infection; Pro-inflammatory cytokines; Toll-like receptors; Ag presentation; Cell death;

    Abstract : The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during Salmonella infection. READ MORE

  5. 13. On the role of innate cell interactions in inflammation and leukemia

    Author : Rebecca E Riise; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate immunity; neutrophils; NK cells; caspase-1; apoptosis; myeloid leukemia; ROS; immunotherapy;

    Abstract : Inflammatory cells of the innate immune system launch rapid and powerful effector responses in the combat against infectious pathogens. However, these inflammatory mediators may cause excessive damage to the host and, therefore, require rigid control systems to maintain the delicate balance between prompt clearance of infections and the risk of developing immunopathology. READ MORE

  6. 14. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors

    Author : Andris Elksnis; Per-Ola Carlsson; Nils Welsh; Sergiu-Bogdan Catrina; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; Tyrosine kinase inhibitors; Imatinib; AMPK; Oxidative stress; NADPH-oxidase; NOX; NOX4; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. READ MORE

  7. 15. Modern roles for an ancient system. Intracellular Complement in the regulation of β cell function

    Author : Ewelina Golec; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; Diabetes mellitus; Insulin secretion; CD59; C3; Isoforms; SNARE proteins;

    Abstract : Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. READ MORE