Search for dissertations about: "inflammatory manifestations"

Showing result 11 - 15 of 96 swedish dissertations containing the words inflammatory manifestations.

  2. 11. Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases

    Author : Juliana Imgenberg-Kreuz; Gunnel Nordmark; Ann-Christine Syvänen; Johanna K Sandling; Amr Sawalha; Uppsala universitet; []
    Keywords : Autoimmunity; DNA methylation; Primary Sjögren’s syndrome; Systemic lupus erythematosus; Gene expression; Type I interferon system; Epigenetics; Medicinsk vetenskap; Medical Science;

    Abstract : Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. READ MORE

  4. 12. Gateway to the gut : alterations in saliva in inflammatory bowel disease

    Author : Mirjam Majster; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inflammatory bowel disease (IBD), which consists of Crohn’s disease and ulcerative colitis, is a chronic immune-mediated disease thought to result from genetic and environmental interaction which influence the commensal flora to trigger an inappropriate mucosal immune response. IBD primarily affects the intestines but is not restricted to them. READ MORE

  5. 13. Studies on pathogenesis, clinical features and comorbidities of idiopathic inflammatory myopathies

    Author : Antonella Notarnicola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Idiopathic inflammatory myopathies (IIM), a group of rare chronic inflammatory disorders, are characterized by a broad spectrum of clinical manifestations with high morbidity and mortality. The pathogenesis of IIM is largely unknown but accumulating evidence suggests that autoantibodies promote the initiation and perpetuation of the disease. READ MORE

  6. 14. Innate and adaptive immune responses in viral and chronic inflammatory diseases

    Author : Danika Schepis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis I address some important questions regarding innate and adaptiveimmune responses in different human diseases. We analysed two distinctconditions: chronic autoimmune inflammation, specifically SLE, and chronic viralinfection, represented by herpes simplex virus (HSV). READ MORE

  7. 15. Studies of different clinical manifestations of Sarcoidosis and the role of genetic factors

    Author : Pernilla Darlington; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Sarcoidosis is a systemic disease of unknown etiology characterized by the formation of non-necrotizing granulomas in the affected organs. Engagement of the lungs and/or thoracic lymph nodes (LN) are found in more than 90 % of all cases, but almost any organ such as the eyes, skin, heart and nervous system can be involved. READ MORE