Search for dissertations about: "inhibitors"

Showing result 1 - 5 of 1196 swedish dissertations containing the word inhibitors.

  1. 1. Design and Synthesis of Galectin Inhibitors

    University dissertation from Microbiology, Immunology and Glycobiology, MIG, Lund University

    Author : Pernilla Sörme; Lunds universitet.; Lund University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parallel Synthesis; Inhibitors; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Carbohydrates; Galectins;

    Abstract : Galectins, a lectin family, have shown binding affinities towards b-galactosides. Galectins have been proposed to be involved in a wide range of functions like for example, cell growth, adhesion, migration, chemo taxis and apoptosis. They have also been associated with various cancer types. READ MORE

  2. 2. Ethanol from lignocellulose : physiological effects of inhibitors and fermentation strategies

    University dissertation from Goteborg, Sweden : Chalmers Tekniska Hogskola

    Author : Mohammad J Taherzadeh; [1999]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Acetic acid; Agents; Cellulose; Enzyme inhibition; Feedback control; Fermentation; Hydrolysis; Metabolites; pH; Physiology; Wood; Yeast; Dilute acid hydrolyzate; Inhibitors; Lignocellulose; Physiological effects; Saccharomyces cerevisiae; Ethanol;

    Abstract : Fermentative ethanol production from dilute-acid hydrolyzates of wood using the yeast Saccharomyces cerevisiae was investigated. Of known inhibitors in hydrolyzates, acetic acid, furfural and hydroxymethyl furfural (HMF) were found in the highest concentrations (up to about 10 g/l). READ MORE

  3. 3. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications

    University dissertation from Lund University, Faculty of Medicine

    Author : John Stegmayr; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectins; inhibitors; evaluation assays; cell culture; idiopathic pulmonary fibrosis; synthetic small-molecule galectin inhibitors; plant-derived polysaccharides;

    Abstract : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. READ MORE

  4. 4. Peptidomimetic Enzyme Inhibitors Targeting M. tuberculosis Ribonucleotide Reductase and Hepatitis C Virus NS3 Protease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johanna Nurbo; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzyme inhibitor; peptidomimetics; structure-activity relationship; tuberculosis; ribonucleotide reductase; hepatitis C virus; NS3 protease; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : This thesis focuses on the design and synthesis of inhibitors targeting Mycobacterium tuberculosis ribonucleotide reductase (RNR) and hepatitis C virus (HCV) NS3 protease; enzymes that have been identified as potential drug targets for the treatment of tuberculosis and hepatitis C, respectively. Small peptides have been recognized as inhibitors of these enzymes. READ MORE

  5. 5. Design and synthesis of HIV-1 protease inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mathias Alterman; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV-1; Protease; Inhibitors; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). The C2-symmetric HIV-1 protease is one of the prime targets for chemotherapy in the treatment of the HIV infection. Inhibition of HIV-1 protease leads to immature and non-infectious viral particles. READ MORE