Search for dissertations about: "inhibitors"

Showing result 21 - 25 of 1474 swedish dissertations containing the word inhibitors.

  2. 21. Proton pump inhibitors: indications and acid rebound

    Author : Anna Niklasson; Göteborgs universitet; []
    Keywords : Proton pump inhibitors; indications; gastrointestinal symptoms; overuse; chronic obstructive pulmonary disease; acid rebound hypersecretion; gastroesophageal reflux disease;

    Abstract : Proton pump inhibitors (PPIs) are nowadays the therapy of choice in the management of a variety of upper gastrointestinal (GI) conditions particularly gastroesophageal reflux disease (GERD). Previous studies indicate that patients commonly receive PPIs without clear indications. READ MORE

  4. 22. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery

    Author : Sofia Svahn Gustafsson; U. Helena Danielson; Johan Neyts; Uppsala universitet; []
    Keywords : Biokemi; Biochemistry;

    Abstract : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. READ MORE

  5. 23. Extracorporeal immunoadsorption

    Author : Christian Freiburghaus; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Klinisk kemi; Clinical chemistry; tolerance induction; inhibitors; haemophilia; Extracorporeal immunoadsorption; antibody elimination; serology; transplantation; Immunologi; serologi;

    Abstract : Antibodies are important protein structures in the immunological defence. Occasionally the regulation of the production of these antibodies fails and antibodies directed against self structures are produced in large scale. Antibody production can also complicate or make transfusions and transplantations impossible. READ MORE

  6. 24. HEMOPHILIA A AND B WITH SPECIAL REFERENCE TO INHIBITOR DEVELOPMENT AND EXPERIMENTAL STUDIES OF FACTORS VIII AND IX

    Author : Karin Knobe; Enheten för pediatrisk hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; inhibitors; mutations; Factor IX; Factor VIII; coagulation; hemophilia A and B; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : The general objective of the research underlying this dissertation was to conduct clinical and basic scientific studies to further elucidate the hemophilia and the coagulation process, with the goal of improving the care of families with these disorders. More specific aims were to evaluate epidemiological, genetic, clinical, and biochemical aspects of the development of inhibitors (antibodies) against FVIII and FIX in Swedish patients with hemophilia A and B (papers I, II, and III). READ MORE

  7. 25. Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease

    Author : Jenny Klintman; Malmö Klinisk koagulationsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hemophilia A; inhibitors; non-neutralizing anti-FVIII antibodies; thrombin generation assay; ELISA;

    Abstract : Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life have increased. READ MORE