Search for dissertations about: "inner hair cell"
Showing result 1 - 5 of 24 swedish dissertations containing the words inner hair cell.
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1. Hair cell regeneration in vestibular epithelia : a study in an in vitro model
Abstract : BackgroundHair cells (HCs) are the sensory receptors in both the auditory and the vestibular organs of the inner ear. Supporting cells (SCs) are non-sensory cells embracing the HCs. Injuries of the HCs by aging, acoustic trauma or ototoxic drugs (mainly aminoglycosides, e.g. READ MORE
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2. Stem cell in-vitro strategies for the induction of sensory neurons for inner ear cell therapy
Abstract : The cochlea, a part of the auditory system, is a complex structure consisting of several different types of cells including hair cells and spiral ganglion neurons. In mammals, the regenerative potential of hair cells and spiral ganglion neurons is lost soon after the birth and damage to any of these cells causes sensorineural hearing loss. READ MORE
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3. Hair cell and organ of corti responses to normal and intense acoustic stimulation
Abstract : The principal aims of the studies described in this thesis were to develop an in vitro model for studying acoustic overstimulation at the cellular level, to define the electrical and mechanical response characteristics of the perfused temporal bone preparation, and to investigate the effects of intense sound stimulation on the calcium levels of the hair cells in the intact hearing organ. In the in vitro model for acoustic overstimulation, isolated cochlear outer hair cells were subjected to a pressure jet emanating from a glass micropipette aimed at the cell body. READ MORE
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4. Pharmacokinetics and inner ear transport of cisplatin
Abstract : Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible hearing loss. READ MORE
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5. K+ channels in the inner ear : electrophysiological and molecular studies
Abstract : Potassium channels are involved in several fundamental cellular processes. Heavy metals, such as mercury and lead, are widespread toxic pollutants and have been shown to act on various ion channels in the central nervous system. READ MORE