Search for dissertations about: "insulin like growth factor"

Showing result 1 - 5 of 227 swedish dissertations containing the words insulin like growth factor.

  2. 1. Insulin-like Growth Factor-I (IGF-I) and Interleukin-6 (IL-6) regulate body fat

    Author : Kristina Wallenius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin-like growth factor I IGF-I ; interleukin-6 IL-6 ; growth hormone GH ; GH releasing factor GHRF ; GH secretagogue GHS ; receptor; leptin; insulin; glucose; intracerebroventricular ICV ; dual-energy X-ray absorptiometry DXA ; indirect calorimetry.;

    Abstract : The aim of this thesis was to investigate the role of insulin-like growth factor-I (IGF-I) and interleukin-6 (IL-6) in the regulation of metabolism and body fat mass. Circulating IGF-I is mainly liver derived, while a large part of circulating IL-6 is produced by adipose tissue. READ MORE

  4. 2. Insulin-like Growth Factor System: functional role and regulation in carcinomas

    Author : Ann Rosendahl; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; PTEN; Transforming Growth Factor-beta; Insulin-like Growth Factor; Renal Cell Carcinoma; Cytologi; onkologi; cancer; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : The insulin-like growth factor (IGF) system demonstrates numerous actions during neoplastic growth and is therefore an interesting target with potential clinical implications. While numerous studies have established important roles of the IGF system in regulating cellular growth and survival of several tumor forms, very limited reports exist regarding its role in renal cell carcinoma (RCC). READ MORE

  5. 3. Regulation of intracellular signaling events that modulate insulin action

    Author : Silvia Gogg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; insulin resistance; EGF; Gab 1; insulin receptor substrate; PI3-kinase; ; Thiazolidinediones; PPARã; insulin signaling; glucose transport; adipose tissue; â-cell.;

    Abstract : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. READ MORE

  6. 4. Diabetes in adolescent girls : Endocrine influences on metabolic control with special regard to the GHI/IGF-I Axis

    Author : Maria Halldin Stenlid; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Insulin dependent diabetes; adolescent; growth hormone; insulin-like growth factor-I; insulin-like growth factor binding protein1; insulin sensitivity; pirenzepine; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

    Abstract : Metabolic control frequently deteriorates during puberty in girls with IDDM, and is often accompanied by excessive weight gain. This impairment has been ascribed the peripubertal psychosocial as well as somatic changes. Puberty is characterised by a unique endocrine milieu. READ MORE

  7. 5. GH, IGF-1 and insulin in the regulation of lipid and lipoprotein metabolism

    Author : Fredrik Frick; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth-hormone; insulin-like growth factor-I; insulin; lipoprotein lipase; adipose tissue; muscle tissue; VLDL secretion;

    Abstract : It is well known that growth hormone (GH) has profound effects on lipid and lipoprotein metabolism. Insulin-like growth factor-I (IGF-I) is believed to mediate some of the effects of GH via endocrine and paracrine mechanisms. Moreover, both GH and IGF-I are known to influence insulin secretion. READ MORE