Search for dissertations about: "insulin release"

Showing result 1 - 5 of 213 swedish dissertations containing the words insulin release.

  1. 1. Myxine insulin amino-acid sequence, three dimensional structure, biosynthesis, release, physiological role, receptor binding affinity, and biological activity

    University dissertation from Umeå : Umeå universitet

    Author : Stefan O. Emdin; Umeå universitet.; [1981]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The Atlantic hagfish, Myxlne. glutinosa,is the most primitive vertebrate extant, and it diverged from the main vertebrate evolutionary chain some 500 mi 11 ion years ago. READ MORE

  2. 2. Mechanisms of insulin exocytosis and release

    University dissertation from Physiological Sciences, Lund University, BMC F11, SE-221 84 Lund

    Author : Sebastian Barg; Lund University.; Lunds universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ClC-3; electrophyiology; confocal microscopy; calcium channel; readily releasable pool; exocytosis; insulin; diabetes; green fluorescent protein; Physiology; Fysiologi;

    Abstract : Endocrine cells as well as neurons release their hormones and transmitters by regulated exocytosis. In the pancreatic B-cell, stimuli like glucose initiate biochemical and electrical processes that culminate in influx of Ca2+, which then triggers exocytosis of insulin-containing granules. READ MORE

  3. 3. THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION

    University dissertation from Medical Faculty, Lund University

    Author : Helena Jones; Lund University.; Lunds universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; PDE3B; exocytosis; insulin; diabetes; Medicine human and vertebrates ; Medicin människa och djur ; diabetologi; sekretion; Endokrinologi; diabetology; Endocrinology; secreting systems;

    Abstract : Type 2 diabetes mellitus (T2DM) is characterized by various combinations of ?-cell failure and insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because of inadequate islet adaptation that glucose intolerance develops in T2DM. READ MORE

  4. 4. Pulsatile insulin release from single islets of Langerhans

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johanna Westerlund; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islets of Langerhans; insulin; ELISA; cytoplasmic calcium; oscillations; type 2 diabetes; glucose; diazoxide; potassium; tolbutamide; DNP; antimycin A; iodoacetamide; microfluorometry; fura-2; KATP channels; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. READ MORE

  5. 5. Transport and release of insulin granules during biphasic insulin secretion

    University dissertation from Department of Experimental Medical Science, Lund Univeristy

    Author : Rosita Ivarsson; Lund University.; Lunds universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; granule transport; Myosin 5a; Cyclic AMP; NADPH; Motor protein; Insulin secretion; Cytoskeleton;

    Abstract : Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin granule transport, as well as to study the influence of the nucleotides cAMP and NADPH to this process. READ MORE