Search for dissertations about: "insulin release"

Showing result 16 - 20 of 224 swedish dissertations containing the words insulin release.

  2. 16. Glucose and insulin modulate phagocytosis and production of reactive oxygen metabolites in human neutrophil granulocytes

    Author : Daniel Saiepour; Per-Arne Oldenborg; Janove Sehlin; Olle Stendahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophil granulocytes; glucose; insulin; protein kinase C; diacylglycerol; phagocytosis; respiratory burst; diabetes; Histology; Histologi;

    Abstract : Neutrophil granulocytes play an important role in the host defence against invading microorganisms and constitute the frontline of defence within the innate immune system and are among the first cells to arrive at the site of inflammation. Effective phagocytosis and killing of invading pathogens by neutrophils is of significant importance for successful resistance to infectious diseases. READ MORE

  4. 17. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans

    Author : Balasubramanian Natarajan; Peter Naredi; Richard Padgett; Umeå universitet; []
    Keywords : Insulin; C. elegans; ASNA1; Cisplatin; GRP94; unfolded protein response; SMN1; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. READ MORE

  5. 18. Molecular mechanisms of biphasic insulin secretion

    Author : Nikhil R. Gandasi; Sebastian Barg; Christien Merrifield; Uppsala universitet; []
    Keywords : Exocytosis; Insulin secretion; Membrane trafficking; Microscopy; Diabetes; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Pancreatic beta-cells secrete insulin in response to increase in blood glucose concentration with a rapid first phase and slower, sustained second phase. This secretion pattern is similar in entire pancreas, isolated islets of Langerhans and single beta-cells and it is disrupted in type 2-diabetes. READ MORE

  6. 19. Insulin promotes GABA signalling modulation in both the mouse hippocampus and human CD4+ T cells

    Author : Hayma Hammoud; Bryndis Birnir; Fredrik Elinder; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gamma-aminobutyric acid; hippocampus; tonic currents; CD4 T cells; glucose; insulin; cytokines; proliferation.; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter in the adult mammalian brain, where it mediates several biological functions. Rapid inhibition is predominantly mediated by the activation of GABA-A receptors that are ubiquitously expressed across the central nervous system in a cell-, circuit-, or region-specific manner. READ MORE

  7. 20. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

    Author : Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
    Keywords : Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

    Abstract : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. READ MORE