Search for dissertations about: "insulin resistance adipogenesis"

Showing result 1 - 5 of 10 swedish dissertations containing the words insulin resistance adipogenesis.

  2. 1. Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes

    Author : Mozhgan Dorkhan; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; insulin secretion; glucagon test; insulin resistance; insulin glargine; insulin tolerance test; thiazolidinediones; natriuretic peptides; adiponectin; thyroid associated ophthalmopathy; proinsulin;

    Abstract : Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. READ MORE

  4. 2. Molecular characterization of insulin resistance in the adipose tissue and the effects of thiazolidinediones

    Author : Ann Hammarstedt; Göteborgs universitet; []
    Keywords : IRS-1; PGC-1; adiponectin; insulin resistance; TZD;

    Abstract : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many contries. Insulin resistance plays a central role in the pathogenesis of Type 2 diabetes and can be present for a decade or more before onset of the disease. READ MORE

  5. 3. Interleukin-6 as a mediator of insulin resistance

    Author : Victoria Rotter Sopasakis; Göteborgs universitet; []
    Keywords : ;

    Abstract : A potential role of interleukin (IL)-6 for the metabolic abnormalities seen in obesity and insulinresistance was postulated when it was discovered that circulating IL-6 levels were elevated in obeseand insulin-resistant as well as type 2 diabetic individuals. Later it was shown that the adipose tissuewas a major site of IL-6 production, accounting for 15-35% of the total circulating levels. READ MORE

  6. 4. Hormone-Sensitive Lipase - New roles in adipose tissue biology

    Author : Kristoffer Ström; Molekylär endokrinologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinoid; adipogenesis; adipocyte determination; HSL; WAT;

    Abstract : Obesity is defined as abnormal or excessive fat accumulation that may impair health, and increased knowledge about the enzymes controlling lipid metabolism is of great importance in order to combat this disease. Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from acylglycerols in adipocytes, but also plays important roles in other cell types. READ MORE

  7. 5. Role of nuclear receptors in the regulation of human adipose tissue metabolism

    Author : Prasad G. Kamble; Jan W Eriksson; Ingrid Dahlman; Uppsala universitet; []
    Keywords : human adipose tissue; nuclear receptors; glucocorticoids; estrogen; PPARγ; lipocalin 2; glucose uptake; lipolysis; adipogenesis; genotype-based recall;

    Abstract : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). READ MORE