Search for dissertations about: "insulin secretion"

Showing result 6 - 10 of 402 swedish dissertations containing the words insulin secretion.

  2. 6. Pathogenesis of type 2 diabetes -role of defects in insulin secretion and insulin sensitivity

    Author : Devjit Tripathy; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; Calpain 10 gene; genetics of type 2 diabetes; MODY; Endogenous glucose production; Disposition index; Botnia clamp; IGT; IFG; HOMA; insulin sensitivity; insulin secretion;

    Abstract : Type 2 diabetes is characterised by defects in insulin sensitivity, insulin secretion and increased endogenous glucose production. The relative contribution of each of these defects remains controversial. READ MORE

  4. 7. Transport and release of insulin granules during biphasic insulin secretion

    Author : Rosita Ivarsson; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; granule transport; Myosin 5a; Cyclic AMP; NADPH; Motor protein; Insulin secretion; Cytoskeleton;

    Abstract : Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin granule transport, as well as to study the influence of the nucleotides cAMP and NADPH to this process. READ MORE

  5. 8. Pancreatic Growth and Secretion. An Experimental Study on Growth Factors in Rat and Mouse

    Author : Claes Hjalmarsson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; PBD; insulin; B-cells; bile; pancreatic cancer; intestine; secretion; pancreas; proliferation; tyrphostins; CCK; epidermal growth factor; transforming growth factor alpha; cancerology; Cytologi; onkologi; cancer; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : The pancreas is a central organ in the digestion of food as well as in glucose metabolism. Its two major functions are exocrine and endocrine secretion. READ MORE

  6. 9. Origin, release and functional significance of the novel gastric hormone ghrelin

    Author : Charlotta Dornonville de la Cour; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; pharmacognosy; pharmacy; Pharmacological sciences; bone metabolism; energy homeostasis; glucagon; insulin; secretion; pancreastatin; somatostatin; histamine; gastrin; gastric acid secretion; ghrelin; gastric motility; A-like cells; farmakognosi; farmaci; toxikologi;

    Abstract : The novel gastric hormone ghrelin was discovered by virtue of its ability to release growth hormone (GH) via interaction with the so-called GH-secretagogue receptor (GHS-R). Earlier only synthetic agents were known to bind with the GHS-R, hence, ghrelin is the first identified endogenous ligand. READ MORE

  7. 10. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

    Author : Linda Ahlkvist; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

    Abstract : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. READ MORE